Recombinant human PDGF-receptorβ ECD

Price

¥124,000

Availability (in Japan)

0
(Contact us)

（In Japan at 17:00,
Feb 17, 2025 in JST）

Size

100 µg

Data Sheet

SDS

Only available for the customers in Singapore, Taiwan and South Korea

Storage and Stability:
PDGF-Rβ-ECD should be stored at -80℃ (stable for at least 1 year). The buffer contains PBS without preservative. After thawing it should be stored in appropriate small aliquots at -20℃ or -80℃ (stable for at least 2 months).

Production platform:
HEK293 cells using the rPEx™ recombinant protein production platform.

Datasheet URL:
https://products.ipatherapeutics.com/product/p002/

Storage temp.	-80°C	Manufacturer	ImmunoPrecise Antibodies (Europe) BV
Alternative names	PDGF-R-beta, CD140 antigen-like family member B, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1
Background	Product description: Platelet derived growth factor Receptor (PDGF-R) is a tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFβ and PDGFδ and for heterodimers formed by PDGFα and PDGFβ, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of mesangial cells in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFβ, heterodimers formed by PDGFα and PDGFβ or homodimeric PDGFδ -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGF-Rα and PDGF-Rβ. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Residues 33-531 of human PDGF-Rβ containing the extra cellular domain were cloned, the protein was over-expressed in HEK293EBNA1 cells and was purified to homogeneity. The calculated molecular weight of monomeric recombinant human PDGF-Rβ is 56 kDa. Since the protein conains 11 N-linked glycans the protein migrates at an apparent molecular weight of about 90 kDa. The protein contains a C-terminal hexahistidine tag. Reference sequences: Swiss-prot P09619
Product category	Research area Cell surface antigens Cytokine & Growth Factors

The availability is based on the information in Japan at 17:00, Feb 17, 2025 in JST.
The special price is shown in red color.
Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
For storage temparature: RT: room temparature
Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.