Price
¥112,000
Availability (in Japan)
0
(Contact us)
(In Japan at 00:05,
Feb 17, 2025 in JST)
Size
100 µg
Only available for the customers in Singapore, Taiwan and South Korea
Storage and Stability:Storage temp. | -80°C | Manufacturer | ImmunoPrecise Antibodies (Europe) BV | ||
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Alternative names | anaphylatoxin, anaphylatoxin C5a analog, complement C5 isoform 1 preproprotein, Complement component 5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, prepro-C5, C5a anaphylatoxin | ||||
Background | Product description: The C5 protein is the fifth component of complement and plays an important role in inflammatory and cell killing processes. C5 is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. Residues 678-751 of human C5 were cloned, the protein was over-expressed in HEK293EBNA1 cells and was purified to homogeneity. The calculated molecular weight of recombinant human C5a is 9.5 kDa and it contains an N-terminal hexahistidine tag. Reference sequences: Swiss-prot P01031 |
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