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HOME > Product search results > Code No. U-C008-01 Recombinant human C5a

Code No. U-C008-01

Recombinant human C5a

Price

¥112,000

Availability (in Japan)

0
(Contact us)

(In Japan at 00:05,
Feb 17, 2025 in JST)

Size

100 µg

Only available for the customers in Singapore, Taiwan and South Korea

Storage and Stability:
Recombinant C5a should be stored at -80℃ (stable for at least 1 year). The enzyme is stored in PBS. After thawing it should be stored in appropriate small aliquots at -20℃ or -80℃ (stable for at least 2 months).

Production platform:
HEK293 cells using the rPEx™ recombinant protein production platform.

Datasheet URL:
https://products.ipatherapeutics.com/product/c008/
Storage temp. -80°C Manufacturer ImmunoPrecise Antibodies (Europe) BV
Alternative names anaphylatoxin, anaphylatoxin C5a analog, complement C5 isoform 1 preproprotein, Complement component 5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, prepro-C5, C5a anaphylatoxin
Background Product description:
The C5 protein is the fifth component of complement and plays an important role in inflammatory and cell killing processes. C5 is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
Residues 678-751 of human C5 were cloned, the protein was over-expressed in HEK293EBNA1 cells and was purified to homogeneity. The calculated molecular weight of recombinant human C5a is 9.5 kDa and it contains an N-terminal hexahistidine tag.

Reference sequences: Swiss-prot P01031
Product category
Research area
Immunology
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