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HOME > Product search results > Code No. U-B002-01 Crystallization grade recombinant complement Factor B

Code No. U-B002-01

Crystallization grade recombinant complement Factor B

Price

¥96,000

Availability (in Japan)

0
(Contact us)

(In Japan at 00:05,
Feb 17, 2025 in JST)

Size

100 µg

Only available for the customers in Singapore, Taiwan and South Korea

Storage and Stability:
Factor B should be stored at -80℃ (stable for at least 1 year). The buffer contains 25 mM Tris 150 mM NaCl pH 7.5 without preservative. After thawing it should be stored in appropriate small aliquots at -20℃ or -80℃ (stable for at least 2 months).

Production platform:
HEK293 cells using the rPEx™ recombinant protein production platform.

Datasheet URL:
https://products.ipatherapeutics.com/product/b002/
Storage temp. -80°C Manufacturer ImmunoPrecise Antibodies (Europe) BV
Background Product description:
Complement factor B is a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.
The cDNA coding for Factor B was cloned and expressed in HEK293EBNA1 cells that are deficient in an enzyme that is involved in N-linked glycosylation of glycoproteins. As a result, recombinant factor B produced from this cell line contains N-linked glycans of the short and simple man5-GlcNAc2 type. Therefore, this factor B is extremely suitable for protein crystallization experiments. Factor B is purified to homogeneity. It contains an N-terminal hexahistidine tag.
Product category
Research area
Immunology
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