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HOME > Product search results > Code No. CY-1178 CycLex® IKKα and β Kinase Assay/Inhibitor Screening Kit

Code No. CY-1178

CycLex® IKKα and β Kinase Assay/Inhibitor Screening Kit

Price

¥90,000

Special price

¥63,000

(ends 2020/03/31)

 > 

Availability (in Japan)

0
(Contact us)

(In Japan at 00:05,
Jan 26, 2020 in JST)

Size

96 Assay

Data

Components Microplate, 10X Wash Buffer, Kinase Buffer, 20X ATP, Anti-Phospho-IkappaBbeta S32 Monoclonal Antibody (AS-2E8), HRP conjugated Anti-mouse IgG, Substrate Reagent, Stop Solution
Intended use This Kit designed to measure the activities of purified IKKα and IKKβ for the rapid and sensitive evaluation of inhibitors or activators.
Storage temp. 4°C Manufacturer MBL
Related products CY-E1178-2 CycLex IKKβ Positive Control
Citations
  1. Harada S et al. Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFκB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency. J Pharmacol Sci. 115, 89-93 (2011)(PMID:21258168)
  1. Qiu J et al. Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanism. PNAS. 110, 18162-7 (2013)(PMID:24145431)
  1. Fakhrudin N et al. Identification of plumericin as a potent new inhibitor of the NF-κB pathway with anti-inflammatory activity in vitro and in vivo. Br J Pharmacol. 171, 1676-86 (2014)(PMID:24329519)
  1. Heyninck K et al. Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ. Biochem Pharmacol. 91, 501-9 (2014)(PMID:25159986)
  1. Parhira S et al. Inhibition of IKK-β by epidioxysterols from the flowers of Calotropis gigantea (Niu jiao gua). Chin Med. 11, 9 (2016)(PMID:26937251)
  1. Kashyap T et al. Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death. Oncotarget 7, 78883-78895 (2016)(PMID:27713151)
  1. Tominari T et al. Effects of O-methylated (-)-epigallocatechin gallate (EGCG) on LPS-induced osteoclastogenesis, bone resorption, and alveolar bone loss in mice. FEBS Open Bio. 7,1972-1981 (2017)(PMID:29226083)
  1. Hirata N et al. Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity. Nutrients. 11, pii: E368 (2019)(PMID:30744180)
  1. Pontoriero M et al. Activation of NF-κB in B cell receptor signaling through Bruton's tyrosine kinase-dependent phosphorylation of IκB-α. J Mol Med (Berl). 97, 675-690 (2019) (PMID:30887112)
Product category
Research area
Drug discovery
Signal transduction
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