||Microplate (coated with recombinant Protein-X as Polo-like kinase 1 substrate), 10X Wash Buffer Kinase Buffer, 20X ATP, Anti-Phospho-Serine/Threonine Monoclonal Antibody(PTS-07) Substrate Reagent, HRP conjugated Anti-mouse IgG, Stop Solution
||This Kit is designed to measure the activities of purified polo-like kinase 1 (Plk1) for the rapid and sensitive evaluation of inhibitors using recombinant Plk1.
||CY-E1163 Plk1 positive control
- Hyo-Eun Yoon, Soo-A Kim, Hong Seok Choi, Mee-Young Ahn, Jung-Hoon Yoon, Sang-Gun Ahn; Inhibition of Plk1 and Pin1 by 5’-nitro-indirubinoxime suppresses human lung cancer cells. Cancer Letters. 316: 97-104. 2012(PMID:22115795)
- Kim SM et al. Enhanced cellular uptake of a TAT-conjugated peptide inhibitor targeting the polo-box domain of polo-like kinase 1. Amino Acids. 46, 2595-603 (2014)(PMID:25151148)
- Srinivasrao G et al. Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1. PLoS One. 9, e107432 (2014)(PMID:25211362)
- Research area