Antibody detailed product information

Code No.	W357-3
Anti-CD105 (Endoglin) (Human) mAb
Price	¥52,800
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 17:33, Apr 26, 2024 in JST）
Clonality	Monoclonal
Clone	3G4A6
Isotype (Immunized Animal)	Mouse IgG2bκ
Applications	FCM　1-10 µg/mL
Immunogen (Antigen)	Human CD105 (Endoglin) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity [Gene ID]	Human[2022]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	END, HHT1, ORW1
Background	Endoglin, also known as CD105, is a type I membrane protein. Endoglin is a major glycoprotein located on the cell surface of vascular endothelium. It is involved in regulation of angiogenesis. In cancer tissue, endoglin is over-expressed in proliferating endothelial cells which line tumor blood vessels. Moreover, tumor cells also express endoglin in prostate cancer and melanoma. Endoglin might be a good candidate to be used for tumor imaging and for targeted cancer therapy.
Related products	W164-3 Anti-RHBDD3 (Human) mAb M077-3 Mouse IgG2b (isotype control) MTG-001 Clear Back (Human Fc receptor blocking reagent)
Product category	Research area:Cancer Tools:Flow cytometry reagents
Data
References	Kojima T, Kitamura T. A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol. 17, 487-90 (1999) Castonguay R et al. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 286, 30034-46 (2011) Chen Y et al. Soluble endoglin modulates aberrant cerebral vascular remodeling. Ann Neurol. 66, 19-27 (2009) Lee NY et al. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. J Biol Chem. 283, 32527-33 (2008) Bellón T et al. Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur J Immunol. 23, 2340-5 (1993)

The availability is based on the information in Japan at 17:33, Apr 26, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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