Antibody detailed product information

Code No. W029-3 プリントPrint out
Anti-IGFBP1 (Human) mAb
Price ¥48,000
Size 100 µg/100 µL
Availability (in Japan) 10 or more
(In Japan at 00:05, Jul 3, 2022 in JST)
Clonality Monoclonal
Clone 2B9-2
Isotype
(Immunized Animal)
Mouse IgG2bκ
Applications FCM 1-10 µg/mL  
Immunogen
(Antigen)
Human IGFBP1 expressed Ba/F3transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity [Gene ID]

Human[3438]

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names AFBP, IBP1, PP12, IGF-BP25, hIGFBP-1
Background IGFBP1, also known as placental protein 12 (PP12), is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin domain. IGFBP1 circulates in the plasma and has been shown to either inhibit or stimulate the growth promoting effects of its ligands called insulin-like growth factors (IGFs) I and II. High expression levels of IGFBP1 have been implicated in metastasis of prostate cancer.
Related products M076-3 Mouse IgG2a (isotype control)
MTG-001 Clear Back (Human Fc receptor blocking reagent)
W164-3 Anti-RHBDD3 (Human) mAb
Product category Research area:Cancer
Tools:Flow cytometry reagents
Data

References
  1. Kojima T, Kitamura T. A signal sequence trap based on a constitutively active cytokine receptor. Nat Biotechnol. 17, 487-90 (1999)(PMID: 10331810
  2. Dolcini L et al. Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. . 276, 6033-46 (2009)(PMID: 197650
  3. Sala A et al. Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid. J Biol Chem. 280, 29812-9 (2005)(PMID: 15972819
  4. Jones JI et al. Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101. J Biol Chem.  268, 1125-31 (1993)(PMID: 7678248
  • The availability is based on the information in Japan at 00:05, Jul 3, 2022 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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