Antibody detailed product information

Code No. RN123PW
Anti-YTHDF2 pAb
Price ¥52,800
Size 100 µL (1 mg/mL)
Availability (in Japan) 10 or more
（In Japan at 17:00, Apr 20, 2024 in JST）
Clonality Polyclonal
Clone Polyclonal
Isotype
(Immunized Animal) 		Rabbit Ig (aff.)
Applications WB　1:1,000  
IP　5 µL/500 µL of cell extract from 5 x 106 cells/sample  
IC*　reported.  （PMID: 30065315）
Reactivity [Gene ID]

Human[51441], Mouse[213541], Rat(w)[313953], Hamster[100763174]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names CAHL, HGRG8, NY-REN-2
Background N(6)-methyladenosine (m6A) is one of the most abundant modified nucleosides found in some viral RNA and eukaryotic RNA including mRNA, tRNA, rRNA and lncRNA. It has been reported that m6A modification is involved in the regulation of mRNA export, stability and translation. YTH N(6)-methyladenosine RNA binding protein 2 (YTHDF2), functioning as m6A reader protein, is involved in methylation-dependent RNA degradation. YTHDF2 selectively binds to m6A-containing RNA through its C-terminal domain and its N-terminal domain is required for localization of the protein-m6A-containing RNA complex to P-body.
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Product category Research area:RNA-RNP Network Epigenetics Cancer
Data


Citations

Western Blotting

  1. Li M et al. Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biol. 19, 69 (2018)(PMID:29855337)
  2. Li Z et al. Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 28, 904-917 (2018)(PMID:30065315)

Immunocytochemistry

  1. Li Z et al. Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res. 28, 904-917 (2018)(PMID:30065315)
  • The availability is based on the information in Japan at 17:00, Apr 20, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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