Antibody detailed product information

Code No. PM077 プリントPrint out
Anti-5-hydroxymethylcytosine (5hmC) pAb
Anti-5-hydroxymethylcytosine (5hmC) pAb is useful for dot blot and hMeDIP. 5hmC is enriched in brain, liver and stem cells and may function as a regulator of gene activation.
Price ¥60,000
Size 100 µL
Availability (in Japan) 10 or more
(In Japan at 17:30, Aug 10, 2022 in JST)
Clonality Polyclonal
Clone Polyclonal
Isotype
(Immunized Animal)
Rabbit Ig (aff.)
Applications IP 2 μL/sample  
IH Can be used. (paraffin section)  
DB 1:5,000  
Immunogen
(Antigen)
BSA-conjugated 5-hydroxymethylcytidine
Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names 5-hmC
Background DNA methylation is one of many critical epigenetic modifications. In most cases, cytosine (C) in DNA sequence is converted to 5-methylcytosine (5mC) with addition of a methyl group by the enzymatic activity of DNA methyltransferase. DNA methylation plays a role in the regulation of gene expression. It has been reported that abnormal DNA methylation level is involved in many diseases.

5-hydroxymethylcytosine (5hmC), a newly identified epigenetic modification following 5mC, is generated from oxidation of 5mC by the enzymatic activity of TET family proteins. 5hmC may function as a regulator of gene expression as well as 5mC.

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Product category Research area:Epigenetics
Data



  • The availability is based on the information in Japan at 17:30, Aug 10, 2022 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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