Antibody detailed product information

Code No.	PM066
Anti-p62 C-terminal pAb
Price	¥43,900
Size	100 µL
Availability (in Japan)	10 or more （In Japan at 17:00, Apr 17, 2026 in JST）
Clonality	Polyclonal
Clone	Polyclonal
Isotype (Immunized Animal)	Guinea pig Ig (aff.)
Applications	WB　1:1,000 IP　5 µL/300 µL of cell extract from 3x10⁶ cells IC　1:500 IH　1:100
Immunogen (Antigen)	Human p62 C-terminal peptide
Reactivity [Gene ID]	Human[8878], Mouse[18412], Rat[113894], Hamster[100768352]
Storage buffer	"PBS/50% glycerol, pH 7.2"
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	"SQSTM1, sequestosome 1, p62"
Background	"p62/SQSTM1 interacts with various molecular groups such as RIP, TRAF6, ERK, aPKCs, and poly-ubiquitin through PB1 domain, Zn finger domain, and UBA domain. This protein directly interacts with LC3, which is localized on autophagosome membrane, and is degradated by autophagic-lysosome pathway. p62 regulates ubiquitin-positive protein aggregates caused by autophagy deficiency."
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Product category	Research area:Autophagy
Data
Citations	Western Blotting Takahashi K et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci. Rep. 7, 2817 (2017)(PMID:28588238) De Pace R et al. Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome. PLoS Genet. 14, e1007363 (2018)(PMID:29698489) Qian Q et al. Hepatic Lysosomal iNOS Activity Impairs Autophagy in Obesity. Cell Mol Gastroenterol Hepatol. 8, 95-110 (2019)(PMID:30926581) Sakai H et al. Upregulation of ubiquitinated proteins and their degradation pathway in muscle atrophy induced by cisplatin in mice. Toxicol Appl Pharmacol. 403, 115165 (2020)(PMID:32738330) Immunocytochemistry Matsumoto G et al. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci Rep. 8, 9585 (2018)(PMID:29941919) Manirujjaman M et al. Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy. Cells. 9, 218 (2020)(PMID:31952347) Yamamoto YH et al. ERdj8 governs the size of autophagosomes during the formation process. J Cell Biol. 219, e201903127 (2020)(PMID:32492081) Immunohistochemistry Kimura H et al. Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy. JCI Insight. 2, e89462 (2017)(PMID:28097232) Takahashi K et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci. Rep. 7, 2817 (2017)(PMID:28588238)

The availability is based on the information in Japan at 17:00, Apr 17, 2026 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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