Antibody detailed product information

Code No.	MEX002-4
Anti-CD63 (LAMP-3) mAb-FITC
Price	¥35,200
Size	100 µL (500 µg/mL)
Availability (in Japan)	10 or more （In Japan at 17:00, Jan 14, 2025 in JST）
Clonality	Monoclonal
Clone	C047-1
Isotype (Immunized Animal)	Mouse IgG2bκ
Applications	FCM　5 µg/mL
Immunogen (Antigen)	human prostate carcinoma cell line (PC3) derived exosomes (prepared by ultracentrifugation from cultured supernatant)
Reactivity [Gene ID]	Human[928]
Storage buffer	500 µg/mL in PBS containing 1% BSA and 0.1% ProClin 150
Storage temp.	冷蔵
Conjugate	FITC
Manufacturer	MBL
Alternative names	MIC3, MRP-1, BTCC-1, DRAP-27, TSPAN29, TSPAN-29
Background	CD63 antigen, also known as LAMP-3, is a tetraspanin characterized by four transmembrane domains and a member of the transmembrane 4 superfamily. CD63 is the first characterized tetraspanin. CD63 has broad tissue distribution and may play multiple roles in a variety of cellular processes such as immune response and tumorigenesis, but its function has not been elucidated entirely. It is reported that CD63 is abundant in tetraspanin-enriched microdomains (TEMs) and a certain type of cellular compartment, such as late endosomes and lysosomes, while the tetraspanin-rich small lipid bilayers are secreted into extracellular fluid as a certain type of extracellular vesicles, called exosome. Because of various exosome features, CD63, one of the representative exosome surface proteins, is thought to be related to intercellular communication.
Related products	MEX001-4 Anti-CD9 mAb-FITC MEX001-3 Anti-CD9 mAb MEX002-3 Anti-CD63 (LAMP-3) mAb MEX003-3 Anti-CD81 (TAPA1) mAb MEX003-4 Anti-CD81 (TAPA1) mAb-FITC MEX001-6 Anti-CD9 mAb-Biotin MEX002-6 Anti-CD63 (LAMP-3) mAb-Biotin MEX003-6 Anti-CD81 (TAPA1) mAb-Biotin M077-4 Mouse IgG2b (isotype control)-FITC MEX001-12 Anti-CD9 mAb-ALP MEX002-12 Anti-CD63 (LAMP-3) mAb-ALP MEX003-12 Anti-CD81 (TAPA1) mAb-ALP D263-3 Anti-CD63 (LAMP-3) (Mouse) mAb
Product category	Research area:Cancer Cell surface antigens Exosomes
Data
References	Mitsunari T et al. Clathrin adaptor AP-2 is essential for early embryonal development. Mol Cell Biol. 25, 9318-23 (2005)（PMID: 16227583） Nishida K et al. Fc{epsilon}RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane. J Cell Biol. 170, 115-26 (2005)（PMID: 15998803） Kabu K et al. Zinc is required for Fc epsilon RI-mediated mast cell activation. J Immunol. 177, 1296-1305 (2006)（PMID: 16818790） Liu Y et al. An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. J Exp Med. 204, 93-103 (2007)（PMID: 17190838） Simons M, Raposo G. Exosomes--vesicular carriers for intercellular communication. Curr Opin Cell Biol. 21, 575-81 (2009)（PMID: 19442504） Pols MS, Klumperman J. Trafficking and function of the tetraspanin CD63. Exp Cell Res. 315, 1584-92 (2009)（PMID: 18930046） Yoshioka Y et al. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun. 5, 3591 (2014)（PMID: 24710016） Melo SA et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523, 177-82 (2015)（PMID: 26106858）

The availability is based on the information in Japan at 17:00, Jan 14, 2025 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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