Antibody detailed product information

Code No. M226-3 プリントPrint out
Anti-ATAD2 (ANCCA) (Human) mAb
Price ¥48,000
Size 100 µg/100 µL
Availability (in Japan) 10 or more
(In Japan at 00:05, Oct 19, 2019 in JST)
Clonality Monoclonal
Clone C20-19
Isotype
(Immunized Animal)
Mouse IgG1 κ
Applications WB 1 μg/mL  
IP 5 μg/sample  
IC 1 μg/mL  
IH 5 μg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen
(Antigen)
Recombinant protein, corresponding to amino acids 1159-1350 of human ATAD2 (ANCCA)
Reactivity [Gene ID]

Human[29028], Mouse(-), Rat(-), Monkey(-)

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names ATPase family AAA domain-containing protein 2, CT137, PRO2000
Background ATAD2, also known as ANCCA, belongs to the AAA type ATPase family and contains a bromodomain, which involves in recognition of an epigenetic histone modification (acetylated lysine). High expression levels of ATAD2 protein are observed in various cancer tissues, and its overexpression in breast and lung cancer is associated with poor tumor prognosis. The bromodomain region of ATAD2 is increasingly targeted for chemical inhibitors used to treat cancer.
Related products D319-3 Anti-Brg1 (Smarca4) mAb
M075-3 Mouse IgG1 (isotype control)
Product category Research area:Epigenetics Cancer
Tools:Molecular pathology tools
Data




References
  1. Kalashnikova EV et al. ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2. Cancer Res 70, 9402-12 (2010)(PMID: 20864510
  2. Ciró M et al. ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res 69, 8491-8 (2009)(PMID: 19843847
  • The availability is based on the information in Japan at 00:05, Oct 19, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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