Antibody detailed product information

Code No. M147-3
Anti-Borealin (Human) mAb
Price ¥52,800
Size 100 µL (1 mg/mL)
Availability (in Japan) 10 or more
（In Japan at 17:33, Apr 26, 2024 in JST）
Clonality Monoclonal
Clone 1D11
Isotype
(Immunized Animal) 		Mouse IgG2a
Applications WB　1 μg/mL  
IP　1 µg/50 µL of cell extract from 1 x 106 cells  
IC　1-5 μg/mL  
Immunogen
(Antigen)		 Recombinant Human full length Borealin
Reactivity [Gene ID]

Human[55143]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names CDCA8, cell division cycle associated 8, BOR, DasraB, MESRGP; BOREALI
Background Borealin is a subunit of the chromosomal passenger complex (CPC), which is necessary for chromosome segregation and cytokinesis. While CPC shows a dynamic localization pattern during mitosis, Borealin and survivin, another subunit of CPC is essential to localize CPC at centromare from prophase to anaphase. It is thought that Borealin and survivin recruit aurora B, a kinase subunit of CPC, to inner centromare to allow phosphorylating appropriate substrates.
Related products M076-3 Mouse IgG2a (isotype control)
Product category Research area:Cancer
Data

Citations
  1. Labarrade F et al. CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities.  Int J Cosmet Sci. (2016) In press.(PMID:26859314)

Immunocytochemistry

  1. Weiderhold KN et al. Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. PLoS One 11, e0153455 (2016)(PMID:27074040)
  • The availability is based on the information in Japan at 17:33, Apr 26, 2024 in JST.
  • The special price is shown in red color.
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  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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