Antibody detailed product information

Code No. M100-3
Anti-CD11c (Mouse) mAb
Price ¥30,800
Size 100 µL (1 mg/mL)
Availability (in Japan) 10 or more
（In Japan at 00:05, Dec 12, 2025 in JST）
Clonality Monoclonal
Clone 223H7
Isotype
(Immunized Animal) 		Rat IgG2a
Applications IP　5 µg/1000 µL of cell extract from 5x106 cells  
FCM　5-10 µg/mL (final concentration)  
IH*　reported.  （PMID: 20042501 / 24695531 / 24752483）
Immunogen
(Antigen)		 C57BL/6 Mice-derived dendritic cells
Reactivity [Gene ID]

Mouse[16411]
Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names Itgax, integrin apha X
Background The CD11c (alpha X integrin; ~150 kDa) glycoprotein non-covalently associates with CD18 (beta2 integrin; ~95 kDa) to form the heterodimeric complement receptor type 4 (CR4), which is involved in monocyte/granulocyte adhesion during inflammatory responses. The CD11c/CD18 receptor binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c/CD18 is also implicated in B cell proliferation and mediates B cell binding to fibrinogen. CD11c is commonly used as a marker for dendritic cells, but it is also expressed on macrophages, monocytes, granulocytes, NK cells, activated T and B lymphocytes and microglia.
Related products M100-4 Anti-CD11c (Mouse) mAb-FITC
M100-6 Anti-CD11c (Mouse) mAb-Biotin
Product category Research area:Immunology Cell surface antigens
Data


Citations

Flow Cytometry

  1. Crawford JR et al. FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation. J Leukoc Biol. 92, 699-711 (2012)(PMID:22493081)
  2. Pilling D, Gomer RH. Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One 9, e93730 (2014)(PMID:24695531)

Immunohistochemistry

  1. Ferreira CS et al. Measles virus infection of alveolar macrophages and dendritic cells precedes spread to lymphatic organs in transgenic mice expressing human signaling lymphocytic activation molecule (SLAM, CD150). J Virol. 84, 3033-42 (2010)(PMID:20042501)
  2. Pilling D, Gomer RH. Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice. PLoS One 9, e93730 (2014)(PMID:24695531)
  3. Catani JP et al.Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma. Transl Oncol. 9, 565-574 (2016)(PMID:24752483)
  • The availability is based on the information in Japan at 00:05, Dec 12, 2025 in JST.
  • The special price is shown in red color.
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  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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