Antibody detailed product information

Code No. K0186-3 プリントPrint out
Anti-HLA-A2 (Human) mAb
Price ¥30,000
Size 100 µg/100 µL
Availability (in Japan) 10 or more
(In Japan at 00:05, Jan 27, 2020 in JST)
Clonality Monoclonal
Clone BB7.2
Isotype
(Immunized Animal)
Mouse IgG2b
Applications IP 1 µg/200 uL of cell extract from 5x106 cells  
FCM 1 µg/mL (final concentration)  
IH 10 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
Immunogen
(Antigen)
papain solubilized HLA-A2
Reactivity [Gene ID]

Human

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Background Human leukocyte antigen-A2 (HLA-A2) is a class I molecule of the human major histocompatibility complex (MHC). It is a heterodimer composed of a 43 kDa α subunit that is non-covalently associated with the 12 kDa β2-microglobulin protein. HLA-A2, like other class I molecules, binds peptides from proteins degraded in the cytoplasm and plays a role in antigen presentation and interaction with CD8+ T cells. HLA-A2 is the most common HLA-A allele in the Caucasian and American Indian populations (50% and ~30%, respectively) and A2 restricted T cell epitopes have been studied widely.
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Product category Research area:Immunology Cell surface antigens
Data

Citations
  1. Wu F et al. Human effector T cells derived from central memory cells rather than CD8(+)T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy. Cancer Lett. 339, 195-207 (2013)(PMID:23791878)

Flow Cytometry

  1. Kozako T et al. Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patients. J Immunol. 177, 5718-26 (2006)(PMID:17015761)
  • The availability is based on the information in Japan at 00:05, Jan 27, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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