Antibody detailed product information

Code No.	K0046-4
Anti-Integrin α7 (Mouse) mAb-FITC
Price	¥22,000
Size	100 µL (500 µg/mL)
Availability (in Japan)	10 or more （In Japan at 17:00, Apr 19, 2024 in JST）
Clonality	Monoclonal
Clone	3C12
Isotype (Immunized Animal)	Mouse IgG1
Applications	FCM　25-50 µg/mL (final concentration)
Immunogen (Antigen)	Mouse myoblasts
Reactivity [Gene ID]	Mouse[16404]
Storage buffer	500 µg/mL in PBS/1% BSA/0.1% ProCin 150
Storage temp.	4°C
Conjugate	FITC
Manufacturer	MBL
Alternative names	Itga7, integrin alpha 7
Background	The integrin family of adhesion molecules participate in important cell-cell and cell-extracellular matrix interactions in a diverse range of biological processes. Integrins are heterodimers consisting of α subunit and β subunit. Both a and b subunit are transmembrane proteins with large extracellular domains (>100 kDa for α subunit and >75 kDa for β subunit) that interact with extracellular matrix proteins and relatively small cytoplasmic domains (50 amino acids or less, except for the β4 subunit) that interact with cytoskeletal proteins. The adhesiveness of integrins is dynamically regulated in response to cytoplasmic signals, termed “inside-out” signaling. It has been reported that, upon ligand binding, integrins regulate many intracellular signaling pathways that involve cytoplasmic alkalization, intracellular Ca²⁺ fluctuation, inositol lipid metabolism, protein kinase C, MAP kinase and phosphatidyl inositol kinase. Integrin α7 is a specific cellular receptor for the basement membrane protein laminin-1, as well as for the laminin isoforms-2 and -4. The α7 subunit is expressed mainly in skeletal and cardiac muscle and may be involved in differentiation and migration processes during myogenesis. Absence of integrin α7 results in muscular dystrophy is revealed.
Related products	K0046-3 Anti-Integrin α7 (Mouse) mAb K0046-5 Anti-Integrin α7 (Mouse) mAb-PE
Product category	Research area:Cell surface antigens
Citations	Flow Cytometry Acharyya S et al. TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One 5, e12479 (2010)(PMID:20814569) Yoshida T et al. Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration. J Biol Chem. 288, 23823-32 (2013)(PMID:23831688)

The availability is based on the information in Japan at 17:00, Apr 19, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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