Code No. | D370-3H | Print out |
Anti-HLA class I (HLA-A,B,C) (Human) mAb | ||
This antibody (clone EMR8-5.1) is validated with automated slide stainers. | ||
Price | ¥32,000 | |
Size | 6 mL | |
Availability (in Japan) | 10 or more
(In Japan at 17:00, Mar 28, 2024 in JST) |
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Clonality | Monoclonal | |
Clone | EMR8-5.1 | |
Isotype (Immunized Animal) |
Mouse IgG1 κ | |
Applications | IH Ready for use. (Heat treatment is necessary for paraffin-embedded sections.) |
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Immunogen (Antigen) |
Recombinant HLA-A*24:02 extracellular domain | |
Reactivity [Gene ID] | ||
Storage buffer | PBS/1% BSA/0.09% NaN3 | |
Storage temp. | 4°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | pan-HLA | |
Background | Human major histocompatibility complex (MHC) class I antigen-epitope peptide complex associated with β2-microglobulin are expressed by all human nucleated cells. It plays an important role in cell-mediated immune responses. Abnormalities in MHC class I antigen surface expression are frequently found in malignancies and infectious diseases. They are often associated with reduced recognition by MHC class I antigen-restricted, tumor or virus-associated antigen-specific cytotoxic T lymphocytes and disease progression. The EMR8-5.1 monoclonal antibody reacts with a non-polymorphic epitope of human MHC class I antigens, HLA-A, -B, and -C. This antibody is suitable for study of MHC class I down-regulation using routine formalin-fixed paraffin-embedded sections by immunohistochemistry. | |
Related products | D367-3 Anti-HLA class I (HLA-A,B,C) (Human) mAb |
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Product category | Research area:Immunology Cancer | |
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