Antibody detailed product information

Code No.	D358-3
Anti-IL-38 (IL1F10) (Human) mAb
Price	¥55,500
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 17:00, Aug 18, 2026 in JST）
Clonality	Monoclonal
Clone	H127C
Isotype (Immunized Animal)	Mouse IgG2bκ
Applications	WB　1 µg/mL IP　5 µg/2 µg recombinant protein IH*　reported. （PMID: 29124228 / 28727766 / 28942884） ELISA*　reported. （PMID: 29124228）
Immunogen (Antigen)	Recombinant full-length Human IL-38 protein
Reactivity [Gene ID]	Human[84639]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Background	Interleukin (IL)-38, a novel cytokine of the IL-1 cytokine family, is homologous to IL-1 receptor antagonist (IL-1Ra) and IL-36Ra, and has been reported to act as an antagonist. IL-38 expression is found in tonsil, placenta, thymus, spleen, fetal liver, and salivary glands, and recent studies suggest a relationship with pathogenesis of inflammatory diseases. High expression levels of IL-38 are also observed in tumor cells and are reported in association with poor prognoses of lung adenocarcinoma patients.
Related products	D359-3 Anti-IL-38 (IL1F10) (Human) mAb D044-3 Anti-IL-18 (Human) mAb D045-3 Anti-IL-18 (Human) mAb D046-3 Anti-IL-18 (Mouse) mAb D047-3 Anti-IL-18 (Mouse) mAb D048-3 Anti-IL-18 (Mouse) mAb M161-3 Anti-IL-33 (Mouse) mAb M187-3 Anti-IL-33 (Mouse) mAb (Functional Grade) M188-3 Anti-IL-33 (Mouse) mAb (Functional Grade) PM033 Anti-IL-33 (Human) pAb
Product category	Research area:Immunology Cancer
Data
References	Takenaka SI et al. IL-38: A new factor in rheumatoid arthritis. Biochem Biophys Rep. 4, 386-391 (2015)（PMID: 29124228） Takada K et al. Clinical implications of the novel cytokine IL-38 expressed in lung adenocarcinoma: Possible association with PD-L1 expression. PLoS One 12, e0181598 (2017)（PMID: 28727766） Tominaga M et al. Overexpression of IL-38 protein in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. Respir Investig. 55, 293-299 (2017)（PMID: 28942884）

The availability is based on the information in Japan at 17:00, Aug 18, 2026 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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