Code No. | D355-3 | |
Anti-Dab1 (Mouse) mAb | ||
Price | ¥52,800 | |
Size | 100 µL (1 mg/mL) | |
Availability (in Japan) | 1-9
(In Japan at 17:33, Apr 26, 2024 in JST) |
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Clonality | Monoclonal | |
Clone | 4E12 | |
Isotype (Immunized Animal) |
Rat IgG2aκ | |
Applications | WB 1 µg/mL IC* reported. (PMID: 25149914) IH* reported. (PMID: 25149914) |
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Immunogen (Antigen) |
Mouse Dab1 (recombinant) | |
Reactivity [Gene ID] | Mouse[13131] |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | disabled 1, scm, scr, yot, AI956902, scrambler, C630028C02Rik | |
Background | Dab1は、神経細胞の移動・配置、樹状突起の発達などに関与する細胞内アダプタータンパク質で、脳の形成に必須な役割を持つ。 クローン4H11は、Dab1のC末(281-460)にエピトープを持ち、クローン4E12はDab1のinternal 領域でPTB(Phosphotyrosine binding )ドメインの近傍(161-320)にエピトープがある。 Reelinが受容体分子(ApoER2/VLDLR)に結合後、Dab1をリン酸化し、細胞内シグナル伝達が進行する。
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Related products | D354-3 Anti-Dab1 (Mouse) mAb D351-3 Anti-Reelin (Mouse) mAb M067-3 Anti-Apolipoprotein E4 (Human) mAb M068-3 Anti-Apolipoprotein E (Human) mAb D352-3 Anti-Kiaa0319 (Mouse) mAb D353-3 Anti-Kiaa0319 (Mouse) mAb |
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Product category | Research area:Neuroscience | |
Data | ||
Citations | Western Blotting
Immunocytochemistry
Immunohistochemistry
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References |
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