Code No. |
D341-4 |
Anti-CD4 (Mouse) mAb-FITC
|
Price |
¥27,500
|
Size |
1 mL (100 tests) |
Availability (in Japan) |
10 or more
(In Japan at 00:05, Apr 18, 2024 in JST)
|
Clone |
GK1.5 |
Isotype
(Immunized Animal) |
Rat IgG2bκ |
Applications |
FCM 10 µL (Ready for use.)
|
Immunogen
(Antigen) |
Cloned cytotoxic T lymphocyte lines V4 and 243/2.5 |
Reactivity [Gene ID] |
Mouse[12504] |
Storage buffer |
PBS containing 1% BSA and 0.09% NaN3 |
Storage temp. |
4°C |
Conjugate |
FITC |
Manufacturer |
MBL |
Alternative names |
L3T4, Ly-4 |
Related products |
M090-4 Rat IgG2b (isotype control)-FITC
|
Product category |
Research area:Immunology |
Data |
|
References |
- Dialynas DP et al. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev. 74, 29-56 (1983)(PMID: 6195085)
- Dialynas DP et al. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131, 2445-2451 (1983)(PMID: 6415170)
- Rice JC and Bucy RP. Differences in the degree of depletion, rate of recovery, and the preferential elimination of naive CD4+ T cells by anti-CD4 monoclonal antibody (GK1.5) in young and aged mice. J. Immunol. 154: 6644-6654 (1995) [depletion](PMID: 7539027)
- Buller RM et al. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells. Nature 328: 77-79 (1987)(PMID: 2955227)
- Li J et al. Complete regression of experimental solid tumors by combination LEC/chTNT-3 immunotherapy and CD25(+) T-cell depletion. Cancer Res., 63: 8384-8392 (2003) [depletion](PMID: 14679000)
- Janssen EM et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434: 88-93 (2005)(PMID: 15744305)
- Ye X et al. Transient depletion of CD4 lymphocyte improves efficacy of repeated administration of recombinant adenovirus in the ornithine transcarbamylase deficient sparse fur mouse. Gene Ther, 7: 1761-1767 (2000)(PMID: 11083498)
- Moro K et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463: 540-544 (2010)(PMID: 20023630)
- Murooka TT et al. HIV-infected T cells are migratory vehicles for viral dissemination. Nature 490: 283-287 (2012) [IHC](PMID: 22854780)
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