Antibody detailed product information

Code No. D341-4
Anti-CD4 (Mouse) mAb-FITC
Price ¥27,500
Size 1 mL (100 tests)
Availability (in Japan) 10 or more
（In Japan at 00:05, Apr 18, 2024 in JST）
Clone GK1.5
Isotype
(Immunized Animal) 		Rat IgG2bκ
Applications FCM　10 µL (Ready for use.)  
Immunogen
(Antigen)		 Cloned cytotoxic T lymphocyte lines V4 and 243/2.5
Reactivity [Gene ID]

Mouse[12504]
Storage buffer PBS containing 1% BSA and 0.09% NaN3
Storage temp. 4°C
Conjugate FITC
Manufacturer MBL
Alternative names L3T4, Ly-4
Related products M090-4 Rat IgG2b (isotype control)-FITC
Product category Research area:Immunology
Data

References
  1. Dialynas DP et al. Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev. 74, 29-56 (1983)（PMID: 6195085）
  2. Dialynas DP et al. Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. J. Immunol. 131, 2445-2451 (1983)（PMID: 6415170）
  3. Rice JC and Bucy RP. Differences in the degree of depletion, rate of recovery, and the preferential elimination of naive CD4+ T cells by anti-CD4 monoclonal antibody (GK1.5) in young and aged mice. J. Immunol. 154: 6644-6654 (1995) [depletion]（PMID: 7539027）
  4. Buller RM et al. Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells. Nature 328: 77-79 (1987)（PMID: 2955227）
  5. Li J et al. Complete regression of experimental solid tumors by combination LEC/chTNT-3 immunotherapy and CD25(+) T-cell depletion. Cancer Res., 63: 8384-8392 (2003) [depletion]（PMID: 14679000）
  6. Janssen EM et al. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434: 88-93 (2005)（PMID: 15744305）
  7. Ye X et al. Transient depletion of CD4 lymphocyte improves efficacy of repeated administration of recombinant adenovirus in the ornithine transcarbamylase deficient sparse fur mouse. Gene Ther, 7: 1761-1767 (2000)（PMID: 11083498）
  8. Moro K et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463: 540-544 (2010)（PMID: 20023630）
  9. Murooka TT et al. HIV-infected T cells are migratory vehicles for viral dissemination. Nature 490: 283-287 (2012) [IHC]（PMID: 22854780）
  • The availability is based on the information in Japan at 00:05, Apr 18, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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