Antibody detailed product information

Code No. D218-3 プリントPrint out
Anti-Desmoglein 3 (Mouse) mAb (No Azide)
Price ¥52,000
Size 100 µg/100 µL
Availability (in Japan) 10 or more
(In Japan at 17:00, Aug 13, 2020 in JST)
Clonality Monoclonal
Clone AK18
Isotype
(Immunized Animal)
Mouse IgG1
Applications IP* reported.  (PMID: 12574390)
IC 0.1 µg/mL  
IH 0.1 µg/mL  
Reactivity [Gene ID]

Human(w)[1830], Mouse[13512]

Storage buffer 1 mg/mL in PBS, pH 7.2
Storage temp. 4°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names DSG3, PVA, CDHF6
Background Pemphigus vulgaris (PV) is a life -threatening autoimmune blistering disease of the skin and mucous membranes. In patients of PV, IgG autoantibodies against the cell surface of keratinocytes in stratified squamous epithelia play a major pathogenic role in loss of cell-cell adhesion. The autoimmune target of PV is desmoglein 3 (Dsg3) which is a member of the cadherin family of calcium-depending, transmembrane glycoprotein.
Related products D217-3 Anti-Desmoglein 3 (Mouse) mAb (No Azide)
D219-3 Anti-Desmoglein 3 (Mouse) mAb (No Azide)
Product category Research area:Immunology
Data


Citations

Western Blotting

  1. Culton DA et al. Mucosal pemphigus vulgaris anti-Dsg3 IgG is pathogenic to the oral mucosa of humanized Dsg3 mice. J Invest Dermatol. 135, 1590-7 (2015)(PMID:25695683)

Immunoprecipitation

  1. Tsunoda K et al. Induction of pemphigus phenotype by a mouse monoclonal antibody against the amino-terminal adhesive interface of desmoglein 3. J Immunol. 170, 2170-8 (2003)(PMID:12574390)

Immunohistochemistry

  1. Culton DA et al. Mucosal pemphigus vulgaris anti-Dsg3 IgG is pathogenic to the oral mucosa of humanized Dsg3 mice. J Invest Dermatol. 135, 1590-7 (2015)(PMID:25695683)
  2. Fujii E et al. Tissue-specific Effects of an anti-desmoglein-3 ADCC Antibody Due to Expression of the Target Antigen and Physiological Characteristics of the Mouse Vagina. J Toxicol Pathol. 33, 67-76 (2020)(PMID:32425339)
  • The availability is based on the information in Japan at 17:00, Aug 13, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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