Code No. | D204-4 | |
Anti-CD52 (CAMPATH-1) (Mouse) mAb-FITC | ||
Price | ¥33,000 | |
Size | 100 µL (500 µg/mL) | |
Availability (in Japan) | 10 or more
(In Japan at 00:05, Feb 11, 2025 in JST) |
|
Clonality | Monoclonal | |
Clone | BTG-2G | |
Isotype (Immunized Animal) |
Rat IgG2aκ | |
Applications | FCM 20 µg/mL (final concentration) |
|
Immunogen (Antigen) |
mouse IL-2Ralpha-transgenic mice splenocytes | |
Reactivity [Gene ID] | Mouse[23833] |
|
Storage buffer | 500 µg/mL in PBS/1% BSA/0.1% ProClin150 | |
Storage temp. | 冷蔵 | |
Conjugate | FITC | |
Manufacturer | MBL | |
Background | CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. The function of CD52 is unknown. However, CD52 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry. | |
Related products | D204-5 Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE D204-3 Anti-CD52 (CAMPATH-1) (Mouse) mAb |
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Product category | Research area:Immunology Cancer Cell surface antigens |