Code No. | D204-3 | |
Anti-CD52 (CAMPATH-1) (Mouse) mAb | ||
Price | ¥44,000 | |
Size | 100 µL (1 mg/mL) | |
Availability (in Japan) | 10 or more
(In Japan at 00:05, Feb 9, 2025 in JST) |
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Clonality | Monoclonal | |
Clone | BTG-2G | |
Isotype (Immunized Animal) |
Rat IgG2a | |
Applications | IP Can be used. FCM 10 µg/mL (final concentration) Function* reported. (PMID: 29899181) |
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Immunogen (Antigen) |
mouse IL-2R alpha-transgenic mouse splenocytes | |
Reactivity [Gene ID] | Mouse[23833] |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Background | CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. The function of CD52 is unknown. However, CD52 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~8-9 kDa as confirmed by total structure analysis and mass spectrometry. | |
Related products | D204-5 Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE D204-4 Anti-CD52 (CAMPATH-1) (Mouse) mAb-FITC |
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Product category | Research area:Immunology Cancer Cell surface antigens | |
Data | ![]() |
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