Antibody detailed product information

Code No. D198-3
Anti-CD93 (Human) mAb
Price ¥46,200
Size 100 µL (1 mg/mL)
Availability (in Japan) 10 or more
(In Japan at 00:05, Jun 14, 2024 in JST)
Clonality Monoclonal
Clone mNI-11
Isotype
(Immunized Animal)
Mouse IgG1
Applications IP 2 µg/400 µg of cell extract from 5x106 cells  
FCM 5 µg/mL (final concentration)  
IH 10 µg/mL (Can be used in cryosections.)  
Co-IP* reported.  (PMID: 29763414)
Immunogen
(Antigen)
LPS-stimulated U937
Reactivity [Gene ID]

Human[22918]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C
Conjugate Unlabeled
Manufacturer MBL
Alternative names C1qRp
Background CD93, also known as C1qRp, is a 100-125 kDa type I membrane protein that is a receptor for the complement protein C1q. CD93 has also been shown to act as a receptor for mannose-binding lectin and surfactant protein A. CD93 is expressed on the surface of monocytes, granulocytes, and endothelial cells, and expression is increased by TNF-α or GM-CSF. CD93 is involved in ligand-mediated enhancement of phagocytosis and intercellular adhesion.
Related products D198-5 Anti-CD93 (Human) mAb-PE
Product category Research area:Cell surface antigens
Data



Citations

Western Blotting

  1. Lugano R et al. CD93 promotes integrin-β1 activation and fibronectin fibrillogenesis during tumor angiogenesis. J Clin Invest. (2018) In press.(PMID:29763414)

Co-IP

  1. Lugano R et al. CD93 promotes integrin-β1 activation and fibronectin fibrillogenesis during tumor angiogenesis. J Clin Invest. (2018) In press.(PMID:29763414)

Flow Cytometry

  1. McGreal EP et al. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J Immunol. 15, 5222-32 (2002)(PMID:11994479)

Immunocytochemistry

  1. Lugano R et al. CD93 promotes integrin-β1 activation and fibronectin fibrillogenesis during tumor angiogenesis. J Clin Invest. (2018) In press.(PMID:29763414)
  2. Barbera S et al. The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration. Cell Commun Signal. 17, 55 (2019)(PMID:31138217)
References
  1. Ikewaki N, Inoko H. Development and characterization of a novel monoclonal antibody (mNI-11) that induces cell adhesion of the LPS-stimulated human monocyte-like cell line U937. J Leukoc Biol. 59, 697-708 (1996)(PMID: 8656055
  2. Ikewaki N et al. A unique monoclonal antibody mNI-11 rapidly enhances spread formation in human umbilical vein endothelial cells. J Clin immunol. 20, 317-24 (2000)(PMID: 10939719
  3. McGreal EP et al. Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q. J Immunol. 168, 5222-32 (2002)(PMID: 11994479
  4. Ikewaki N et al. Regulation of CD93 cell surface expression by protein kinase C isoenzymes. Microbiol Immunol. 50, 93-103 (2006)(PMID: 16490927
  5. Ikewaki N et al. Decrease in CD93 (C1qRp) expression in a human monocyte-like cell line (U937) treated with various apoptosis-inducing chemical substances. Microbiol Immunol. 51, 1189-200 (2007)(PMID: 18094537
  6. Ikewaki N et al. Flow cytometric identification of CD93 expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood. J Clin Immunol.30, 723-33 (2010)(PMID: 20512406
  7. Ikewaki N et al. Unique properties of cluster of differentiation 93 in the umbilical cord blood of neonates. Microbiol Immunol. 57, 822-32 (2013)(PMID: 24033555
  8. Ikewaki N et al. Serum levels of soluble CD93 in patients with chronic renal failure. J. of Kyushu Univ. of Health and Welfare 17, 81-8 (2016)
  9. Nativel B et al. CD93 is a cell surface lectin receptor involved in the control of the inflammatory response stimulated by exogenous DNA. Immunology. 158, 85-93 (2019)(PMID: 31335975
  10. Małgorzata K et al. Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients. Biomolecules.11(11) 1623 (2021)(PMID: 34827620
  • The availability is based on the information in Japan at 00:05, Jun 14, 2024 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.
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