Antibody detailed product information

Code No.	D133-3M2
Anti-CD279 (PD-1) (Human) mAb (Functional Grade)
Price	¥79,200
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 00:05, Feb 16, 2025 in JST）
Clonality	Monoclonal
Clone	J105
Isotype (Immunized Animal)	Mouse IgG1
Applications	FCM　5 µg/mL
Immunogen (Antigen)	Fc-fusion human PD-1 protein
Reactivity [Gene ID]	Human[5133]
Storage buffer	1 mg/mL in PBS. Azide free, 0.22 μm sterile-filtered
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	PDCD1, programmed cell death 1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Background	Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.
Related products	M075-3M2 Mouse IgG1 (isotype control) (Functional Grade) D133-3 Anti-CD279 (PD-1) (Human) mAb D133-5 Anti-CD279 (PD-1) (Human) mAb-PE D132-3 Anti-CD279 (PD-1) (Human) mAb D132-4 Anti-CD279 (PD-1) (Human) mAb-FITC D132-5 Anti-CD279 (PD-1) (Human) mAb-PE D092-3 Anti-CD274 (PD-L1) (Human) mAb D230-3 Anti-CD274 (PD-L1) (Human) mAb D230-5 Anti-CD274 (PD-L1) (Human) mAb-PE D092-3M2 Anti-CD274 (PD-L1) (Human) mAb (Functional Grade)
Product category	Research area:Immunology Cancer Apoptosis Cell surface antigens
Data
References	Iwai Y et al. Microanatomical localization of PD-1 in human tonsils. Immunol Lett. 83, 215-20 (2002)（PMID: 12095712） Kanai T et al. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol. 171, 4156-63 (2003)（PMID: 14530338）

The availability is based on the information in Japan at 00:05, Feb 16, 2025 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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