Antibody detailed product information

Code No.	D128-3
Anti-Phospho-STAT3 (Tyr708) mAb
This antibody reacts with human and mouse STAT3 phosphorylated at Tyr705, and zebrafish STAT3 phosphorylated at Tyr708.
Price	¥52,800
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 00:05, Apr 25, 2024 in JST）
Clonality	Monoclonal
Clone	PS3/1
Isotype (Immunized Animal)	Mouse IgG1
Applications	WB　1 µg/mL
Immunogen (Antigen)	12 peptide including phospho-Tyr708 of Zebrafish STAT3 (CVTQPpYLKTKFI) (703-714 a.a.)
Reactivity [Gene ID]	Human[6774], Mouse[20848]
Storage buffer	PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	APRF, HIES
Background	STAT (Signal Transducers and Activators of Transcription) proteins play important roles in development, cell differentiation and cell cycle control. STAT3 is an ~85 kDa protein involved in the signaling pathways of many cytokines and growth factors, including G-CSF and IL-6, where it functions as a negative regulator of transcription. STAT3 is also constitutively activated in a number of human tumors and it possesses anti-apoptotic activity and oncogenic potential. STAT3 may also regulate apoptosis by inhibiting NF-κB. Activation of STAT3 by tyrosine phosphorylation results in dimerization, nuclear translocation and DNA binding.
Product category	Research area:Cancer Signal transduction
Data
Citations	Western Blotting Chen C et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond-Blackfan anemia. Cell Death Dis. 11, 135 (2020)(PMID:32075953)

The availability is based on the information in Japan at 00:05, Apr 25, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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