Code No. | D086-3 | |
Anti-ASC (TMS1) (Human) mAb | ||
Price | ¥52,800 | |
Size | 100 µL (1 mg/mL) | |
Availability (in Japan) | 10 or more
(In Japan at 17:00, Apr 19, 2024 in JST) |
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Clonality | Monoclonal | |
Clone | 23-4 | |
Isotype (Immunized Animal) |
Mouse IgG1 | |
Applications | WB 1 µg/mL IP 5 µg/300 µL of cell extract from 5x106 HL-60 cells IC* reported. (PMID: 10567338 / 15041718) IH* reported. (PMID: 11561011) |
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Immunogen (Antigen) |
Triton X-100 insoluble fraction of retinoic acid-treated HL-60 cells | |
Reactivity [Gene ID] | Human[29108], Mouse(-), Rat(-) |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | PYCARD, TMS, CARD5, TMS-1 | |
Background | ASC (apoptosis-associated speck-like protein containing a CARD (caspase recruitment domain)) is a 22 kDa soluble protein, located in the cytosol of HL-60 cells. In apoptotic HL-60 cells, it is able to be visualized as a speck, forming an insoluble aggregate. The C-terminal domain of this protein contains a CARD, suggesting that ASC may have proapoptotic activity in HL-60 cells. Recent data have indicated that ASC plays a role of adaptor protein linking various PAAD (Pyrin, AIM, ASC, and death domain-like) family proteins to pathways involved in NF-κB and procaspase-1 activation. | |
Related products | D086-A64 Anti-ASC (TMS1) (Human) mAb-Alexa Fluor™ 647 |
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Product category | Research area:Immunology Apoptosis | |
Data | ||
Citations |
Western Blotting
Immunocytochemistry
Immunohistochemistry
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