Antibody detailed product information

Code No.	D046-3
Anti-IL-18 (Mouse) mAb
Price	¥52,800
Size	100 µL (1 mg/mL)
Availability (in Japan)	10 or more （In Japan at 00:05, Apr 20, 2024 in JST）
Clonality	Monoclonal
Clone	39-3F
Isotype (Immunized Animal)	Rat IgG2a
Applications	WB　1 μg/mL Function*　reported. （PMID: 11145690）
Immunogen (Antigen)	Recombinant Mouse IL-18
Reactivity [Gene ID]	Human(-), Mouse[16173]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C
Conjugate	Unlabeled
Manufacturer	MBL
Alternative names	interleukin 18 (interferon-gamma-inducing factor), IGIF, IL1F4, IL-1g
Related products	D047-3 Anti-IL-18 (Mouse) mAb D048-3 Anti-IL-18 (Mouse) mAb D043-3 Anti-IL-18 (Human) mAb D044-3 Anti-IL-18 (Human) mAb D045-3 Anti-IL-18 (Human) mAb PM014 Anti-IL-18 (Human) pAb M157-3 Anti-IL-18 (Rat) mAb M158-3 Anti-IL-18 (Rat) mAb D048-3M2 Anti-IL-18 (Mouse) mAb (Functional Grade) 7625 Mouse IL-18 ELISA Kit D048-6 Anti-IL-18 (Mouse) mAb-Biotin PD039 Anti-cleaved IL-1β (Mouse) pAb D358-3 Anti-IL-38 (IL1F10) (Human) mAb D359-3 Anti-IL-38 (IL1F10) (Human) mAb
Product category	Research area:Immunology Cytokine & Growth Factors
Data
Citations	Western Blotting Hoshino T et al. Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function. J Immunol. 166, 7014-8 (2001)(PMID:11390444) Seino H et al. IL-18 mediates the formation of stress-induced, histamine-dependent gastric lesions. Am J Physiol Gastrointest Liver Physiol. 292, G262-7 (2007)(PMID:16959946) Hoshino T et al. Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med. 176, 49-62 (2007)(PMID:17400729) Venkatachalam K et al. Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. J Biol Chem. 284, 7853-65 (2009) (PMID:19164288) Fujiwara H et al. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nat Commun. 9, 3674 (2018)(PMID:30201970) Yamanishi K et al. Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia. J Transl Med. 16, 314 (2018)(PMID:30453990) Chakravarti D et al. Telomere dysfunction activates YAP1 to drive tissue inflammation.Nat Commun. 11, 4766 (2020) (PMID:32958778) Ambati J et al. Repurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development. Nat Commun. 11, 4737 (2020)(PMID:32968070) Neutralization Lertmemongkolchai G et al. Bystander activation of CD8+ T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens. J. Immunol. 166, 1097-105 (2001)(PMID:11145690)

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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