Code No. | 566 | |
Anti-CD117 (c-Kit) (Human) pAb | ||
Price | ¥63,800 | |
Size | 100 µL | |
Availability (in Japan) | 1-9
(In Japan at 00:05, Feb 12, 2025 in JST) |
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Clonality | Polyclonal | |
Clone | Polyclonal | |
Isotype (Immunized Animal) |
Rabbit IgG | |
Applications | WB 1:1,000 IC 1:200 (Heat treatment is necessary for paraffin embedded sections.) IH 1:200 (Heat treatment is necessary for paraffin embedded sections.) |
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Immunogen (Antigen) |
Carrier protein conjugated synthetic peptide (C-terminal of c-kit gene product (K963)) | |
Reactivity [Gene ID] | Human[3815] |
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Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | |
Storage temp. | -20°C | |
Conjugate | Unlabeled | |
Manufacturer | MBL | |
Alternative names | KIT proto-oncogene receptor tyrosine kinase | |
Background | c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development. | |
Related products | 566-H Anti-CD117 (c-Kit) (Human) pAb |
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Product category | Research area:Stem cell research Cancer Cell surface antigens | |
Data | ![]() ![]() ![]() |
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Citations | Immunohistochemistry
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