Anti-Histone H4 mAb

Price

¥52,800

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 17, 2024 in JST）

Size

100 µL (1 mg/mL)

Data	Immunoprecipitation
Clonality	Monoclonal	Clone	C14691
Isotype (Immunized Animal)	Mouse IgG2b
Applications	WB 1 µg/mL IP 5 µg/200 µL of cell extract from 5x10⁶ cells IC 5 µg/mL
Immunogen (Antigen)	Protein fraction extracted from the mitotic chromosome
Reactivity [Gene ID]	Human, Mouse, Rat, Hamster
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Background	The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The N-terminal tail of core histones undergoes multiple different post-transcriptional modifications including acetylation, phosphorylation, ubiquitination, methylation, and ADP-ribosylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. Acetylation of histone H4 plays a primary role in the structural changes that mediate enhanced binding of transcription factors to their recognition sites within nucleosomes. It has been suggested that acetylated histone H4 is also involved in heightened activation of the transcription of male X chromosomes, and that histone H4 stimulates glucose transport activity in rat skeletal muscle.
Related products	D210-3 Anti-Histone H2A mAb D212-3 Anti-Histone H2B mAb D214-3 Anti-Histone H4 mAb CY-1140 CycLex® Cellular Histone Acetylation Assay Kit
Product category	Research area Epigenetics Cancer

The availability is based on the information in Japan at 00:05, Apr 17, 2024 in JST.
The special price is shown in red color.
Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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