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HOME > Product search results > Code No. D187-3 Anti-Dlk (Pref-1) mAb

Code No. D187-3

Anti-Dlk (Pref-1) mAb



Availability (in Japan)


(In Japan at 00:05,
Jul 1, 2022 in JST)


100 µg/100 µL

  • Flow Cytometry

  • Immunohistochemistry

  • Immunohistochemistry

Clonality Monoclonal Clone 24-11
Isotype (Immunized Animal) Rat IgG1
5-10 µg/mL  
reported.  (PMID: 23943621
10 µg/mL (paraffin), 1 µg/mL (frozen)  
Immunogen (Antigen) Dlk-Fc fusion protein
Reactivity [Gene ID]


Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names delta-like 1 homolog (Drosophila), FA1, ZOG, pG2, DlkI, Peg9, SCP1, DLK-1, Ly107, pref-1, AW742678
Background Delta like protein (Dlk), also known as Preadipocyte factor-1 (Pref-1) or zona glomerulosa-specific factor (ZOG), is an EGF-like transmembrane protein expressed preadipocytes but not in mature adipocytes. It is highly expressed in fetal liver, the adrenal gland, and placenta, as well as some neuroendocrine tumors and small cell lung carcinomas, where it plays a role in differentiation and proliferation. Dlk positively and negatively regulates adipocyte differentiation via at least four major variants (45-60 kDa) of Dlk generated by alternatively splicing. Constitutive expression of Dlk inhibits adipogenesis, but insulin or insulin like growth factor-1 (IGF-1) can circumvent this inhibition. Regulated processing of Dlk releases a 50 kDa soluble form that was previously characterized as Fetal Antigen-1, a protein involved in pancreatic island cell differentiation.
Related products D187-4 Anti-Dlk (Pref-1) mAb-FITC
D187-5 Anti-Dlk (Pref-1) mAb-PE
D118-3 Anti-Liv2 (Mouse) mAb

Flow Cytometry

  1. Khurana S, Mukhopadhyay A. Hematopoietic progenitors from early murine fetal liver possess hepatic differentiation potential. Am J Pathol. 173, 1818-27 (2008)(PMID:18988804)
  2. Cheung PF et al. Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells. PLoS One 6, e28246 (2011)(PMID:22194816)
  3. Kanayama K et al. Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells. Stem Cells Int. 2019:9789240 (2019) (PMID:31065285)


  1. García-Alonso V et al. Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes. J Biol Chem. 288, 28230-42 (2013)(PMID:23943621)


  1. Tan KS et al. Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos. Biol Open 4, 596-607 (2015)(PMID:25887124)
  2. Tan KS et al. Analysis of Hematopoietic Niche in the Mouse Embryo. Methods Mol Biol. 2002, 13-27 (2019)(PMID:30671734)
Product category
Research area
Stem cell research

  • The availability is based on the information in Japan at 00:05, Jul 1, 2022 in JST.
  • The special price is shown in red color.
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  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
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