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HOME > Product search results > Code No. D038-3 Anti-Bcl-2 mAb

Code No. D038-3

Anti-Bcl-2 mAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Oct 23, 2019 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

Clonality Monoclonal Clone 83-8B
Isotype (Immunized Animal) Mouse IgG1
Applications
WB
1 µg/mL  
FCM
10 µg/mL  
Immunogen (Antigen) Recombinant rat Bcl-2β
Reactivity [Gene ID]

Human[596], Mouse[12043], Rat[24224]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names B-cell CLL/lymphoma 2, BCL2, PPP1R50
Background The Bcl-2 related genes can inhibit (Bcl-XL and Mcl-1) or induce (Bax, Bcl-Xs, Bag and Bad) apoptosis in several systems. Bad was identified as a Bcl-2 interacting protein using a yeast two-hybrid screening and l expression cloning. It has homology to Bcl-2 within the Bcl-2 homolog domains 1 and 2 (BH1 and BH2). In mammalian cells, Bad selectively heterodimerizes with Bcl-XL as well as Bcl-2, but not with other Bcl-2 family members (Bax, Bcl-Xs, Mcl-1 and A1). When Bad heterodimerized with Bcl-XL, it displaced Bax from Bcl-XL and promoted cell death.
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Citations

Western Blotting

  1. Tamatani M et al. Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J Biol Chem. 274, 8531-8 (1999)(PMID:10085086)
  2. Tanaka T et al. Resistance to Fas-mediated apoptosis in human lung fibroblast. Eur Respir J. 20, 359-68 (2002)(PMID:12212968)
  3. Rincheval V et al. Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition. Biochem Biophys Res Commun. 298, 282-8 (2002)(PMID:12387829)
Product category
Research area
Apoptosis
Brands
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  • The availability is based on the information in Japan at 17:00, Oct 23, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.