Price
¥66,000
Availability (in Japan)
10 or more
(In Japan at 00:05,
Feb 17, 2025 in JST)
Size
200 µL (1 mg/mL)
Data | |||||
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Clonality | Polyclonal | Clone | Polyclonal | ||
Isotype (Immunized Animal) | Rabbit Ig (aff.) | ||||
Applications |
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Immunogen (Antigen) | KLH-conjugated synthetic peptide NGSMLPNQPSGYRVAGYETQ (367-386 aa) | ||||
Reactivity [Gene ID] | |||||
Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | TIA1 cytotoxic granule-associated RNA binding protein, WDM, TIA-1 | ||||
Background | T-cell intracellular antigen-1 (TIA1), an apoptosis promoting factor, is a RNA binding protein which associates with subsets of mRNAs bearing U-rich sequences in their 3’-UTRs and shuttles between nucleus and cytoplasm. TIA1 possesses three RNA recognition motifs (RRMs). RRM2 and the first half of the auxiliary region are necessary for nuclear accumulation whereas RRM3 mediates nuclear export. TIA1 regulates splicing of alternatively spliced pre-mRNAs including Fas, msl-2, FGFR-2, calsitonin/CGRP in nucleus. In cytoplasm, TIA1 regulates translation of various mRNAs, include TNF-α, Cox-2, HMMP-13 and β2-adrenergic receptor, by binding to AU-rich elements (AREs) located in these mRNA 3’ untranslated regions (3’UTRs). In addition to the translational silencing, TIA1 plays a role in the cellular response to environmental stress by promoting the assembly of a non-canonical 48S preinitiation complex that is the core component of cytoplasmic stress granules (SG). Like other mRNA turnover and translation regulators such as AUF-1, HuR, KSRP and NF90, TIA1 also associates its cognate mRNA and transcripts of other RBPs. | ||||
Related products | RN1001 RIP-Assay Kit RN1005 RIP-Assay Kit for microRNA RN059PW Anti-TIAL1 pAb |
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Citations |
Western Blotting
RNP Immunoprecipitation
Other(eCLIP)
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