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HOME > Product search results > Code No. PM074 Anti-Phospho-p62 (SQSTM1) (Ser351) pAb

Code No. PM074

Anti-Phospho-p62 (SQSTM1) (Ser351) pAb

Price

¥48,000

Availability (in Japan)

10 or more

(In Japan at 00:05,
Nov 17, 2019 in JST)

Size

100 µL

This antibody specifically detects phospho-p62 (Ser351) in WB, IC, IHC
Data
  • Western Blotting

  • Immunoprecipitation

  • Immunocytochemistry

  • Immunohistochemistry

Clonality Polyclonal Clone Polyclonal
Isotype (Immunized Animal) Rabbit Ig (aff.)
Applications
WB
1:500  
IP
2 µL/sample  
IC
1:500  
IH
1:1,000  
Immunogen (Antigen) KLH conjugated synthetic peptide, CKEVDP(pS)TGELQSLQ (corresponding to amino acid residues 346-359 of mouse p62 (SQSTM1))
Reactivity [Gene ID]

Human[8878], Mouse[18412]

Storage buffer PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names Sequestosome-1, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, EBI3-associated protein of 60 kDa, p60, EBIAP, SQSTM1, ORCA, OSIL
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Citations

Western Blotting

  1. Johansson I et al. The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells. Autophagy 11, 1636-51 (2015)(PMID:26237736)
  2. Yoshii SR et al. Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons. Dev Cell 39, 116-130 (2016)(PMID:27693508)
  3. Watanabe Y et al. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy 13, 133-148 (2017)(PMID:27846364)
  4. Yanagisawa H et al. L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease. Sci Rep. 7, 15994 (2017)(PMID:29162837)
  5. Mizunoe Y et al. Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways. Redox Biol. 15, 115-124 (2017)(PMID:29241092)
  6. Bak DH et al. Anti‑apoptotic effects of human placental hydrolysate against hepatocyte toxicity in vivo and in vitro. Int J Mol Med. 42, 2569-2583 (2018)(PMID:30132515)
  7. Jena KK et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62‐NRF2 axis and autophagy. EMBO J. 37, e98358 (2018)(PMID:30143514)
  8. Yamada M et al. p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J. 33, 8022-8032 (2019) (PMID:30913396)

Immunocytochemistry

  1. Watanabe Y et al. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy 13, 133-148 (2017)(PMID:27846364)

Immunohistochemistry

  1. Watanabe Y et al. HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy 13, 133-148 (2017)(PMID:27846364)
References
  1. Ichimura Y et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51,  618-31 (2013)(PMID: 24011591
  2. Kageyama S et al. Proteasome dysfunction activates autophagy and the keap1-nrf2 pathway. J Biol Chem. 289, 24944-55 (2014)(PMID: 25049227
Product category
Research area
Autophagy
Brands
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Nov 17, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.