Availability (in Japan)
（In Japan at 00:05,
Jan 20, 2020 in JST）
|Isotype (Immunized Animal)||Rabbit IgG|
|Immunogen (Antigen)||recombinant region of human ATBF1 (2107-2147 aa.) corresponding to the identical amino acid sequence of mouse ATBF1 (2114-2154 aa.)|
|Reactivity [Gene ID]|
|Storage buffer||PBS/50% glycerol, pH 7.2|
|Alternative names||ZFHX3, ATBT, ZNF927|
|Background||ATBF1 (also known as ZFHX3) is a transcription factor that has two-protein isoforms, the 404 kDa ATBF1-A and the 306 kDa ATBF1-B. ATBF1-A contains four homeodomains and 23 zinc-finger motifs.
ATBF1-B contains four homeodomains and 18 zinc fingers. ATBF1 is identified as DNA-binding protein, which binds to an AT-rich element of the human α-fetoprotein (AFP) gene, as a result suppressing its transcription activity. ATBF1 is also involved in cell cycle arrest and cooperating with p53 to activate the p21Waf1/Cip1 promoter. ATBF1 is expressed in the differentiation fields in association with β-tubulin III and MAP2 that are the neuronal differentiation marker. ATBF1 plays a crucial role in neuronal development and cell cycle arrest.
|Related products||PD011 Anti-ATBF1 (AT-6) pAb