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HOME > Product search results > Code No. M187-3 Anti-IL-33 (Mouse) mAb (Functional Grade)

Code No. M187-3

Anti-IL-33 (Mouse) mAb (Functional Grade)

Price

¥80,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Dec 11, 2019 in JST)

Size

200 µg/200 µL

Data
  • Western Blotting

Clonality Monoclonal Clone 1F11
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
WB
1 μg/mL  
Immunogen (Antigen) Mouse IL-33, 109-266 aa Recombinant protein
Reactivity [Gene ID]

Human(-), Mouse[77125]

Storage buffer 1 mg/mL in PBS
Storage temp. 4°C Conjugate Unlabeled Manufacturer MBL
Alternative names interleukin 33, Il1f11, NF-HEV, 9230117N10Rik
Background Interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, has important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1α/β and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation.
Related products M188-3 Anti-IL-33 (Mouse) mAb (Functional Grade)
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D359-3 Anti-IL-38 (IL1F10) (Human) mAb
Citations

Neutralization

  1. Ohno T et al. Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS One 6, e18404 (2011)(PMID:21494550)
  2. Bunting MM et al. Interleukin-33 drives activation of alveolar macrophages and airway inflammation in a mouse model of acute exacerbation of chronic asthma. Biomed Res Int. 250938 (2013)(PMID:23936781)
  3. Shadie M et al. Ambient particulate matter induces an exacerbation of airway inflammation in experimental asthma: role of interleukin-33. Clin Exp Immunol. (2014) In press.(PMID:24730559)

Function

  1. Saigusa R et al. Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells. Arthritis Res Ther. 20, 23 (2018)(PMID:29415756)
Product category
Research area
Immunology
Cytokine & Growth Factors
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  • The availability is based on the information in Japan at 17:00, Dec 11, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.