Anti-Borealin (Human) mAb

Price

¥52,800

Availability (in Japan)

10 or more

（In Japan at 00:05,
Apr 20, 2024 in JST）

Size

100 µL (1 mg/mL)

Data	Immunoprecipitation
Clonality	Monoclonal	Clone	1D11
Isotype (Immunized Animal)	Mouse IgG2a
Applications	WB 1 μg/mL IP 1 µg/50 µL of cell extract from 1 x 10⁶ cells IC 1-5 μg/mL
Immunogen (Antigen)	Recombinant Human full length Borealin
Reactivity [Gene ID]	Human[55143]
Storage buffer	1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp.	-20°C	Conjugate	Unlabeled	Manufacturer	MBL
Alternative names	CDCA8, cell division cycle associated 8, BOR, DasraB, MESRGP; BOREALI
Background	Borealin is a subunit of the chromosomal passenger complex (CPC), which is necessary for chromosome segregation and cytokinesis. While CPC shows a dynamic localization pattern during mitosis, Borealin and survivin, another subunit of CPC is essential to localize CPC at centromare from prophase to anaphase. It is thought that Borealin and survivin recruit aurora B, a kinase subunit of CPC, to inner centromare to allow phosphorylating appropriate substrates.
Related products	M076-3 Mouse IgG2a (isotype control)
Citations	Labarrade F et al. CRM1 and chromosomal passenger complex component survivin are essential to normal mitosis progress and to preserve keratinocytes from mitotic abnormalities. Int J Cosmet Sci. (2016) In press.(PMID:26859314) Immunocytochemistry Weiderhold KN et al. Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. PLoS One 11, e0153455 (2016)(PMID:27074040)
Product category	Research area Cancer

The availability is based on the information in Japan at 00:05, Apr 20, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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