Price
¥48,000
Availability (in Japan)
10 or more
(In Japan at 17:00,
Mar 29, 2024 in JST)
Size
100 µL (1 mg/mL)
Data | |||||
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Clonality | Monoclonal | Clone | 4G2 | ||
Isotype (Immunized Animal) | Mouse IgG2b | ||||
Applications | |||||
Immunogen (Antigen) | Recombinant Caspase-7 (N-terminal :1-198 a.a.) | ||||
Reactivity [Gene ID] | |||||
Storage buffer | 1 mg/mL in PBS/50% glycerol, pH 7.2 | ||||
Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
Alternative names | CASP7 | ||||
Background | Apoptosis is a major form of cell death characterized by several morphological features that include chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathway that leads to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Caspase-7 (also known as Mch-3 / ICE-LAP3 / CMH-1) is a 35 kDa protein that has the highest similarity to caspase-3 (52% amino acid identity) between all caspase members. It has been involved in ''effector'' caspases (which include caspase 3, 6, 7) that are cleaved by ''initiator'' caspases (which include caspase 8, 9) into active form, and then, in turn cleave various cellular proteins for apoptosis. Recent study says that in Fas mediated hepatocyte apoptosis, active caspase-7 is associated almost exclusively with the mitochondrial and microsomal fractions, whereas active caspase-3 is confined primarily to the cytosol. It implies the different role of caspase-3 and -7 in the execution of apoptosis. | ||||
Related products | M032-3 Anti-Caspase-8 (Human) mAb M058-3 Anti-Caspase-8 (Human) mAb M029-3 Anti-Caspase-4 (Human) mAb M044-3 Anti-XIAP (MIHA/ILP-a) mAb M087-3 Anti-Caspase-3 (Human) mAb M097-3 Anti-Caspase-3 (Human) mAb |
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Citations |
Western Blotting
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