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HOME > Product search results > Code No. K0142-4 Anti-PSMA (Human) mAb-FITC

Code No. K0142-4

Anti-PSMA (Human) mAb-FITC

Price

¥20,000

Availability (in Japan)

10 or more

(In Japan at 17:00,
Dec 12, 2019 in JST)

Size

50 µg/100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 107-1A4
Isotype (Immunized Animal) Mouse IgG1
Applications
FCM
10-20 µg/mL (final concentration)  
Immunogen (Antigen) LNCaP cell homogenate
Reactivity [Gene ID]

Human[2346]

Storage buffer 500 µg/mL in PBS/1% BSA/0.1% ProClin 150
Storage temp. 4°C Conjugate FITC Manufacturer MBL
Alternative names FOLH1, foate hydrolase 1
Background Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein expressed at high levels in prostate cancer and in tumor-associated neovasculature. PSMA is also known as a glutamate carboxypeptidase II (EC 3.4.17.21) that hydrolyzes the neuropeptide, N-acetyl-L-aspartyl-L-glutamate, releasing glutamate, the dominant excitatory neurotransmitter/neuromodulator of the mammalian central nervous system. The ability of PSMA to liberate -glutamate may allow the removal of glutamate residues from dietary folates, which are unable to be transported into cells in their poly--glutamate form. Overexpression of PSMA in prostate cancer cells may represent an advantageous adaptation that allows the uptake of folates required for rapid division. The exopeptidase activity exhibited by PSMA and its high-level overexpression in prostate cancer cells make it a potential target for selective anticancer therapy and prodrug activation.
Related products K0142-3 Anti-PSMA (Human) mAb
K0142-5 Anti-PSMA (Human) mAb-PE
K0142-6 Anti-PSMA (Human) mAb-Biotin
Citations

Flow Cytometry

  1. Chauchereau A et al. Stemness markers characterize IGR-CaP1, a new cell line derived from primary epithelial prostate cancer. Exp Cell Res. 317, 262-75 (2011)(PMID:20974126)
Product category
Cancer
Research area
Cancer
Cell surface antigens
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 17:00, Dec 12, 2019 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.