This site is for customers in Japan. Customers in other regions, please go to Global page.
HOME > Product search results > Code No. D266-6 Anti-Mincle (Mouse) mAb-Biotin

Code No. D266-6

Anti-Mincle (Mouse) mAb-Biotin

Price

¥36,000

Availability (in Japan)

1-9

(In Japan at 00:05,
Jan 20, 2020 in JST)

Size

100 µL

Data
  • Flow Cytometry

Clonality Monoclonal Clone 1B6
Isotype (Immunized Animal) Rat IgG1 κ
Applications
FCM
1:500  
Immunogen (Antigen) RBL-2H3 cells expressing full length mouse mincle
Reactivity [Gene ID]

Mouse[56619]

Storage buffer PBS/1% BSA/0.1% ProClin 150
Storage temp. 4°C Conjugate Biotin Manufacturer MBL
Alternative names Clec4e, C86253, Clecsf9, C-type lectin domain family 4, member e
Background Macrophage-inducible C-type lectin (Mincle, also called as Clec4e and Clecsf9), a type II transmembrane C-type lectin receptor, is expressed mainly in macrophages. Mincle is selectively associated with the Fc receptor common g-chain which contains immunoreceptor tyrosine-based activation motif (ITAM) and activates macrophages to produce inflammatory cytokines and chemokines. Mincle expressing cells are activated by spliceosome associated protein 130 (SAP130) which is a component of small nuclear ribonucleoprotein released from dead cells.

Recently, Mincle is reported to recognize Mycobacterium tuberculosis as well as pathogenic fungus Malassezia species. Mincle is demonstrated to be an essential receptor for a mycobacterial glycolipid, trehalose-6,6’-dimycolate (TDM). The cytokine/chemokine production of macrophages which Malassezia or M.tuberculosis induces in Mincle-/- mice is significantly impaired. Mincle is considered to play a crucial role in immune responses to pathogens.

Related products D292-3 Anti-Mincle (Mouse) mAb
D316-3 Anti-Mincle (Guinea pig) mAb
M191-3 Anti-FcεR1γ (FcRγ) (Mouse) mAb
D266-3M2 Anti-Mincle (Mouse) mAb (Functional Grade)
D292-3M2 Anti-Mincle (Mouse) mAb (Functional Grade)
D360-3 Anti-Mincle (Human) mAb (Functional Grade)
D266-3 Anti-Mincle (Mouse) mAb
Citations
  1.   
References
  1. Miyake Y et al. C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity 38, 1050-62 (2013)
  2. Behler F et al. Role of Mincle in alveolar macrophage-dependent innate immunity against mycobacterial infections in mice. J Immunol. 189, 3121-9 (2012)
  3. Yamasaki S et al. C-type lectin Mincle is an activating receptor for pathogenic fungus Malassezia. PNAS 106, 1897-1902 (2009)
  4. Ishikawa E et al. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med. 206, 2879-2888 (2009
  5. Yamasaki S et al. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol. 9, 1179-88 (2008)
Product category
Research area
Immunology
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Jan 20, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.