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HOME > Product search results > Code No. D238-3 Anti-MORC3 mAb

Code No. D238-3

Anti-MORC3 mAb

Price

¥48,000

Availability (in Japan)

1-9

(In Japan at 00:05,
Aug 13, 2020 in JST)

Size

100 µg/100 µL

Data
  • Western Blotting

Clonality Monoclonal Clone 17A9
Isotype (Immunized Animal) Mouse IgG1 κ
Applications
WB
1-5 μg/mL  
IC
5 μg/mL  
Immunogen (Antigen) Recombinant Human MORC3
Reactivity [Gene ID]

Human[23515], Mouse[338467], Rat[304074]

Storage buffer 1 mg/mL in PBS/50% glycerol, pH 7.2
Storage temp. -20°C Conjugate Unlabeled Manufacturer MBL
Alternative names NXP2, ZCW5, ZCWCC3
Background MORC3 {microrchidia (MORC) family CW-type zinc finger 3, KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conserved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al. reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.
Related products M041-3 Anti-PML (Human) mAb
K0181-3 Anti-p53 (Human) mAb
Citations

Immunoprecipitation

  1. Ceribelli A et al. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Arthritis Res Ther. 14, R97 (2012)(PMID:22546500)

Immunofluorescence

  1. Takahashi K et al. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell 18, 1701-9 (2007)(PMID:17332504)
  2. Mimura Y et al. Two-step colocalization of MORC3 with PML nuclear bodies. J Cell Sci. 123, 2014-24 (2010)(PMID:20501696)
Product category
Cancer
Research area
Cancer
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Aug 13, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications:
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.