Anti-CD184 (CXCR4) mAb-FITC

Price

¥30,000

Availability (in Japan)

10 or more

（In Japan at 00:05,
Jan 18, 2020 in JST）

Size

50 µg/100 µL

Citations

Data Sheet

SDS

Data	Flow Cytometry
Clonality	Monoclonal	Clone	A145
Isotype (Immunized Animal)	Rat IgG1
Applications	FCM 10-20 μg/mL (final concentration)
Immunogen (Antigen)	CXCR4 transfected Cos-1 cells
Reactivity [Gene ID]	Human[7852]
Storage buffer	500 µg/mL in PBS/1% BSA/0.09% NaN₃
Storage temp.	4°C	Conjugate	FITC	Manufacturer	MBL
Alternative names	FB22, HM89, LAP3, LCR1, LESTR, NPY3R, WHIM, D2S201E
Background	CXCR4/CD184/LESTR/fusin/NPY3R is a G protein-coupled receptor for the CXC chemokine SDF-1. Binding of SDF-1 induces CXCR4 phosphorylation by Ser/Thr kinases, leading to CXCR4 internalization via clathrin-coated pits. CXCR4 functions include co-stimulation in pre-B cell proliferation, induction of apoptosis, and HIV entry, since CXCR4 is one of the 2 major HIV/SIV co-receptors. Early infection with HIV-1 is dominated by CCR5-tropic (R5) viruses. The evolution of CXCR4-tropic (X4) viruses occurs later in the infection and is associated with rapid disease progression. CXCR4 mediates chemotaxis in mature and progenitor blood cells and is essential for B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. Although ubiquitously expressed in blood and tissue cells, its role in blood and tissue homeostasis is not fully understood. CXCR4 is predominantly stored intracellularly, and may contribute to the inefficiency in transmission and propagation of X4-tropic viruses.
Related products	D123-3 Anti-CD184 (CXCR4) mAb D070-5 Anti-CX₃CR1 (Human) mAb-PE D070-3 Anti-CX₃CR1 (Human) mAb
Citations	Flow Cytometry Cesano A et al. Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts.Cytometry B Clin Cytom. 82, 158-72 (2012)(PMID:22334473)
References	Cesano A et al. Functional pathway analysis in acute myeloid leukemia using single cell network profiling assay: effect of specimen source (bone marrow or peripheral blood) on assay readouts. Cytometry B Clin Cytom. 82, 158-72 (2012) (PMID:22334473)
Product category	Research area Cell surface antigens Cytokine & Growth Factors

The availability is based on the information in Japan at 00:05, Jan 18, 2020 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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