Price
¥48,000
Availability (in Japan)
10 or more
(In Japan at 00:05,
Dec 16, 2019 in JST)
Size
50 µg/100 µL
Data | |||||
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Clonality | Monoclonal | Clone | 2A9-1 | ||
Isotype (Immunized Animal) | Rat IgG2bκ | ||||
Applications | |||||
Immunogen (Antigen) | Human CX3CR1 expressing non-mammalian cells | ||||
Reactivity [Gene ID] | Human[1524] |
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Storage buffer | 0.5 mg/mL in 10mM NaPB/1% BSA/0.3M NaCl/0.09% NaN3 | ||||
Storage temp. | 4°C | Conjugate | FITC | Manufacturer | MBL |
Alternative names | chemokine (C-X3-C motif) receptor 1, V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1 | ||||
Background | There are several subfamilies in the chemokine superfamily. In addition to CXC, CC, and C subfamily, Fractalkine (FKN), which has the novel CX3C chemokine motif and the mucin-like domain, has recently been identified and reported. This mucin-chemokine hybrid type of protein can exist in two forms; either membrane-bound form or soluble secreted form. The membrane-bound form of FKN protein is markedly induced on primary endothelial cells by inflammatory cytokines, and it promotes strong adhesion of NK cells and CD8+ T cells. The soluble secreted form of FKN can be released, presumably by proteolysis at a membrane-proximal dibasic cleavage site, and has chemotactic activity for these leukocytes. CX3CR1, which is recently identified FKN receptor, is also G-protein-coupled seven-transmembrane receptor as another chemokine receptor families, and is expressed on the cell surface of NK cells and CD8+ T cells. It is also reported that CX3CR1 and FKN mediate both leukocytes migration and adhesion. | ||||
Related products | D070-3 Anti-CX3CR1 (Human) mAb D070-5 Anti-CX3CR1 (Human) mAb-PE D070-A48 Anti-CX3CR1 (Human) mAb-Alexa Fluor® 488 |
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Citations |
Flow Cytometry
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Product category |
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