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HOME > Product search results > Code No. D070-4 Anti-CX3CR1 (Human) mAb-FITC

Code No.　D070-4

Anti-CX3CR1 (Human) mAb-FITC

Price

¥48,000

Availability (in Japan)

10 or more

（In Japan at 00:05,
Jan 22, 2020 in JST）

Size

50 µg/100 µL

Data

  • Flow Cytometry
Clonality Monoclonal Clone 2A9-1
Isotype (Immunized Animal) Rat IgG2bκ
Applications
FCM
10 µg/mL (final concentration)  
Immunogen (Antigen) Human CX3CR1 expressing non-mammalian cells
Reactivity [Gene ID]

Human[1524]
Storage buffer 0.5 mg/mL in 10mM NaPB/1% BSA/0.3M NaCl/0.09% NaN3
Storage temp. 4°C Conjugate FITC Manufacturer MBL
Alternative names chemokine (C-X3-C motif) receptor 1, V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1
Background There are several subfamilies in the chemokine superfamily. In addition to CXC, CC, and C subfamily, Fractalkine (FKN), which has the novel CX3C chemokine motif and the mucin-like domain, has recently been identified and reported. This mucin-chemokine hybrid type of protein can exist in two forms; either membrane-bound form or soluble secreted form. The membrane-bound form of FKN protein is markedly induced on primary endothelial cells by inflammatory cytokines, and it promotes strong adhesion of NK cells and CD8+ T cells. The soluble secreted form of FKN can be released, presumably by proteolysis at a membrane-proximal dibasic cleavage site, and has chemotactic activity for these leukocytes. CX3CR1, which is recently identified FKN receptor, is also G-protein-coupled seven-transmembrane receptor as another chemokine receptor families, and is expressed on the cell surface of NK cells and CD8+ T cells. It is also reported that CX3CR1 and FKN mediate both leukocytes migration and adhesion.
Related products D070-3 Anti-CX3CR1 (Human) mAb
D070-5 Anti-CX3CR1 (Human) mAb-PE
D070-A48 Anti-CX3CR1 (Human) mAb-Alexa Fluor® 488
Citations

Flow Cytometry

  1. Vitale M et al. The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells. Eur J Immunol. 34, 1715-22 (2004)(PMID:15162442)
  2. Makishima H et al. Significance of chemokine receptor expression in aggressive NK cell leukemia. Leukemia 19, 1169-74 (2005)(PMID:15902300)
  3. Lee RH et al. A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice. Blood 107, 2153-61 (2006)(PMID:16278305)
  4. EI-Shazly A et al. Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma. J Immunol. 176, 1860-8 (2006)(PMID:16424217)
  5. Bjerkeli V et al. Increased expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in Wegener's granulomatosis--possible role in vascular inflammation. Reumatology 46, 1422-7 (2007)(PMID:17616549)
  6. Momose K et al. Close resemblance between chemokine receptor expression profiles of lymphoproliferative disease of granular lymphocytes and their normal counterparts in association with elevated serum concentrations of IP-10 and MIG. Int J Hematol. 86, 174-9 (2007)(PMID:17875534)
  7. Liu Y et al. Association between circulating monocyte subsets and in-stent restenosis after coronary stent implantation in patients with ST-elevation myocardial infarction. Circ J. 74, 2585-91 (2010)(PMID:20944435)
  8. Tae Yu H et al. Characterization of CD8(+)CD57(+) T cells in patients with acute myocardial infarction. Cell Mol Immunol. 12, 466-73 (2015)(PMID:25152079)
Product category
Research area
Cell surface antigens
Cytokine & Growth Factors
この製品に関するお問い合わせをする

  • The availability is based on the information in Japan at 00:05, Jan 22, 2020 in JST.
  • The special price is shown in red color.
  • Please note that products cannot be ordered from this website. To purchase the items listed in this website, please contact us or local distributers.
  • Abbreviations for applications：
    WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
    FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
    ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
    DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
  • For applications and reactivity:
    *: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
    **: The use is reported from the licenser (Under evaluation or not tested by MBL).
  • For storage temparature: RT: room temparature
  • Please note that products in this website might be changed or discontinued without notification in advance for quality improvement.