Anti-SynCAM (TSLC1/CADM1) mAb-Biotin

Price

¥63,800

Availability (in Japan)

10 or more

（In Japan at 17:00,
Apr 16, 2024 in JST）

Size

100 µL (1 mg/mL)

Citations

Data Sheet

SDS

Data	Flow Cytometry
Clonality	Monoclonal	Clone	3E1
Isotype (Immunized Animal)	Chicken IgY
Applications	IP* reported. （PMID: 27756895） FCM 1 µg/mL
Immunogen (Antigen)	Recombinant Fc-SynCAM fusion protein
Reactivity [Gene ID]	Human[23705], Rat*[363058](PMID: 27756895)
Storage buffer	1 mg/mL in PBS/1% BSA/0.1% ProClin 150
Storage temp.	4°C	Conjugate	Biotin	Manufacturer	MBL
Alternative names	cell adhesion molecule 1, IgSF4, NECL-2, SgIgSF, TSLC1, CADM1, BL2, ST17, RA175
Background	SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.
Related products	CM004-3 Anti-SynCAM (TSLC1/CADM1) mAb CM005-3 Anti-SynCAM (TSLC1/CADM1) (Human) mAb CM004-A64 Anti-SynCAM (TSLC1/CADM1) mAb-Alexa Fluor™ 647 CM004-4 Anti-SynCAM (TSLC1/CADM1) mAb-FITC PM084 Normal Chicken IgY PM084-4 Normal Chicken IgY-FITC PM084-5 Normal Chicken IgY-PE CM004-5 Anti-SynCAM (TSLC1/CADM1) mAb-PE
Citations	Immunoprecipitation Rademacher N et al. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Sci Rep. 6, 35283 (2016)(PMID:27756895) Flow Cytometry Balan S et al. Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity. Cell Rep. 24, 1902-1915.e6 (2018)(PMID:30110645) Cañete PF et al. Regulatory roles of IL-10-producing human follicular T cells. J Exp Med. 216, 1843-1856 (2019)(PMID:31209070) Makiyama J et al. CD4+ CADM1+ cell percentage predicts disease progression in HTLV-1 carriers and indolent adult T-cell leukemia/lymphoma. Cancer Sci. 110, 3746-3753 (2019) (PMID:31642546)
Product category	Research area Cancer Neuroscience

The availability is based on the information in Japan at 17:00, Apr 16, 2024 in JST.
The special price is shown in red color.
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Abbreviations for applications：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation
FCM: Flow Cytometry, NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
For applications and reactivity:
*: The use is reported in a research article (Not tested by MBL). Please check the data sheet for detailed information.
**: The use is reported from the licenser (Under evaluation or not tested by MBL).
For storage temparature: RT: room temparature
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