Price
¥52,800
Availability (in Japan)
1-9
(In Japan at 00:05,
Nov 12, 2025 in JST)
Size
100 µL
| Data | |||||
|---|---|---|---|---|---|
| Clonality | Polyclonal | Clone | Polyclonal | ||
| Isotype (Immunized Animal) | Rabbit Ig (aff.) | ||||
| Applications |
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| Immunogen (Antigen) | Recombinant Mouse p27kip1 | ||||
| Reactivity [Gene ID] | |||||
| Storage buffer | PBS/50% glycerol, pH 7.2 | ||||
| Storage temp. | -20°C | Conjugate | Unlabeled | Manufacturer | MBL |
| Alternative names | CDKN1B | ||||
| Background | Cyclin dependent kinase inhibitory protein 1 (Kip1) is a 27 kDa inducible inhibitor of cyclin-dependent kinase complexes (CKI). It acts by suppressing S-phase entry and thereby blocking cell cycle progression. Kip1 interacts strongly with D-type cyclins in complex with Cdk4 and weaklier with cyclin E/Cdk2 complex to cause G1 arrest. Kip1 is a potent tumor suppressor for multiple epithelially derived neoplasias, and expression of Kip1 is frequently down regulated in human tumors. Kip1 levels are regulated by phosphorylation and degradation via the ubiquitin-proteosome pathway. | ||||
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