抗体 製品詳細情報

Code No. PM045
Anti-p62 (SQSTM1) pAb
価格(税別) ¥41,800
包装 100 µL
在庫 10以上
（2024/12/14 00:05時点）
クローナリティー Polyclonal
クローン Polyclonal
アイソタイプ
(免疫動物)		 Rabbit Ig (aff.)
使用法 WB　1:1,000  
IP　2 µL/300 µL of cell extract from 1 x 107 cells  
IC　1:500  
IH　1:1,000 (Heat treatment is necessary for paraffin embedded sections.)  
IF*　reported.  
Other(Immuno-EM)　reported.  （PMID: 29109534）
免疫原(抗原) Recombinant Human p62 (120-440 a.a.)
交差性 [Gene ID]

Human[8878], Mouse[18412], Rat[113894], Hamster[100768352], Zebrafish*[406452](PMID: 28924380), Bovine*(PMID: 32199904)
性状 PBS/50% glycerol, pH 7.2
保存温度 -20°C
標識 Unlabeled
メーカー MBL
別称 sequestosome 1, p60, p62, A170, OSIL, PDB3, ZIP3, p62B/Osi, A170, STAP, OSF-6/Osi, ZIP
背景 p62/SQSTM1 interacts with various molecular groups such as RIP, TRAF6, ERK, aPKCs, and poly-ubiquitin through PB1 domain, Zn finger domain, and UBA domain.　This protein directly interacts with LC3, which is localized on autophagosome membrane, and is degradated by autophagic-lysosome pathway. p62 regulates ubiquitin-positive protein aggregates caused by autophagy deficiency.
関連製品 M162-3 Anti-p62 (SQSTM1) (Human) mAb
M162-A48 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 488
M162-A59 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 594
M162-A64 Anti-p62 (SQSTM1) (Human) mAb-Alexa Fluor™ 647
PM066 Anti-p62 C-terminal pAb
8485 Autophagy Ab Sampler Set
PM074 Anti-Phospho-p62 (SQSTM1) (Ser351) pAb
D343-3 Anti-Phospho-p62 (SQSTM1) (Ser403) mAb
D344-3 Anti-Phospho-p62 (SQSTM1) (Ser403) mAb
M152-3 Anti-LC3 mAb
PM090 Anti-Atg8 (Filamentous fungi) pAb
D343-3MS Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set
D344-3MS Anti-Phospho-p62 (SQSTM1) (Ser403) mAb for My select sampler set
M152-3MS Anti-LC3 mAb for My select sampler set
PM074MS Anti-Phospho-p62 (SQSTM1) (Ser351) pAb for My select sampler set
M230-3 Anti-Parkin mAb
M150-3 Anti-Atg16L mAb
PM037 Anti-GABARAP pAb
8486 Autophagy Watch
M135-3 Anti-GABARAP mAb
M186-3 Anti-LC3 mAb
M200-3 Anti-NRF2 mAb
M217-3 Anti-Phospho-p62 (SQSTM1) (Ser351) mAb
M217-3MS Anti-Phospho-p62 (SQSTM1) (Ser351) mAb for My select sampler set
M224-3 Anti-KEAP1 mAb
PD014 Anti-LC3 pAb
PM036 Anti-LC3 pAb
PM038 Anti-GATE-16 pAb
PM040 Anti-Atg16L pAb
PM069 Anti-NRF2 pAb
PM072 Anti-VMP1 pAb
MK-12-3 Anti-Ubiquitin mAb
CY-7055 CycLex® Total p62 ELISA Kit
製品カテゴリー 分野:オートファジー
データ




使用文献

Western Blotting

  1. Waguri S, Komatsu M. Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice. Methods Enzymol. 453, 181-96 (2009)(PMID:19216907)
  2. Otomo T et al. Inhibition of autophagosome formation restores mitochondrial function in mucolipidosis II and III skin fibroblasts. Mol Genet Metab. 98, 393-9 (2009)(PMID:19656701)
  3. Ogata T et al. Fasting-related autophagic response in slow- and fast-twitch skeletal muscle. Biochem Biophys Res Commun. 394, 136-40 (2010)(PMID:20184860)
  4. Itakura E, Mizushima N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol. 192, 17-27 (2011)(PMID:21220506)
  5. Lee EJ, Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 7 689-95  (2011)(PMID:21460635)
  6. Higaki K et al. Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency. Hum Mutat. 32, 843-52 (2011)(PMID:21520340)
  7. Myeku N, Figueiredo-Pereira ME. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem. 286, 22426-40 (2011)(PMID:21536669)
  8. Takamura A et al. Lysosomal accumulation of Trk protein in brain of GM1 -gangliosidosis mouse and its restoration by chemical chaperone. J Neurochem. 118, 399-406 (2011)(PMID:21574998)
  9. Huang Y et al. PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy 7, 1132-44 (2011)(PMID:21673516)
  10. Osawa Y et al. L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of rapamycin. J Biol Chem. 286, 34800-8 (2011)(PMID:21841000)
  11. Frankel LB et al. microRNA-101 is a potent inhibitor of autophagy. EMBO J. 30, 4628-41 (2011)(PMID:21915098)
  12. Takaesu G et al. TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy. J Biochem. 151, 157-66 (2012)(PMID:21976705)
  13. Matsumoto G et al. Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins. Mol Cell 44, 279-89 (2011)(PMID:22017874)
  14. Berliocchi L et al. Autophagy impairment in a mouse model of neuropathic pain. Mol Pain 7, 83 (2011)(PMID:22023914)
  15. Rovetta F et al. ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin. Exp Cell Res. 318, 238-50 (2012)(PMID:22146761)
  16. Wu SY et al. Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation. Neoplasia 13, 1171-82 (2011)(PMID:22241963)
  17. Takasaka N et al. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol. 192, 958-68 (2014)(PMID:24367027)
  18. Hasegawa J et al. Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome. EMBO J. 35, 1853-67 (2016)(PMID:27340123)
  19. Cao QH et al. Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer. Am J Transl Res. 8, 3831-3847 (2016)(PMID:27725863)
  20. Watanabe Y et al. Autophagy controls centrosome number by degrading Cep63. Nat Commun. 7, 13508 (2016)(PMID:27869116)
  21. Wakatsuki S et al. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. J Cell Biol. 216, 477-493 (2017)(PMID:28053206)
  22. Maueröder C et al. Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide. Front Immunol. 8, 16 (2017)(PMID:28191006)
  23. Takayama K et al. Dissection of ubiquitinated protein degradation by basal autophagy. FEBS Lett. 591, 1199-1211 (2017)(PMID:28369861)
  24. Zhao Z et al. Curcumin accelerates the repair of sciatic nerve injury in rats through reducing Schwann cells apoptosis and promoting myelinization. Biomed Pharmacother. 92, 1103-1110 (2017)(PMID:28622711)
  25. Lee J et al. Mice in the early stage of liver steatosis caused by a high fat diet are resistant to thioacetamide-induced hepatotoxicity and oxidative stress. Toxicol Lett. 277, 92-103 (2017)(PMID:28642009)
  26. Kobayashi S et al. Increased ophthalmic acid production is supported by amino acid catabolism under fasting conditions in mice. Biochem Biophys Res Commun. 491, 649-655 (2017)(PMID:28757411)
  27. Zhao Q et al. Dual Roles of Two Isoforms of Autophagy-related Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity. Sci Rep. 7, 11250 (2017)(PMID:28900156)
  28. Meng XH et al. Intracellular Insulin and Impaired Autophagy in a Zebrafish model and a Cell Model of Type 2 diabetes. Int J Biol Sci. 13, 985-995 (2017)(PMID:28924380)
  29. Tamura N et al. Differential requirement for ATG2A domains for localization to autophagic membranes and lipid droplets. FEBS Lett. 591, 3819-3830 (2017)(PMID:29113029)
  30. Sato Y et al. Apobec2 deficiency causes mitochondrial defects and mitophagy in skeletal muscle. FASEB J. 32, 1428-1439 (2017)(PMID:29127187)
  31. Mizunoe Y et al. Trehalose protects against oxidative stress by regulating the Keap1–Nrf2 and autophagy pathways. Redox Biol. 15, 115-124 (2017)(PMID:29241092)
  32. Swinnen B et al. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Acta Neuropathol. 135, 427-443 (2018)(PMID:29302778)
  33. Festa BP et al. Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney. Nat Commun. 9, 161 (2018)(PMID:29323117)
  34. Gatta L et al. Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice. Oncotarget. 8, 113938-113956 (2017)(PMID:29371959)
  35. Ebner P et al. The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun. 9, 599 (2018)(PMID:29426817)
  36. Yamaguchi T et al. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 11, eaan3638 (2018)(PMID:29438013)
  37. Piacentini M et al. Non-alcoholic fatty liver disease severity is modulated by transglutaminase type 2. Cell Death Dis. 9, 257 (2018)(PMID:29449533)
  38. Ito T et al. Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL. Int J Oncol. 53, 503-514 (2018)(PMID:29845256)
  39. Miao X et al. Serum SQSTM1 is a potential predictor for chemotherapeutic efficacy against non-small cell lung . Int J Clin Exp Med. 11, 5811-5819 (2018)
  40. Zhan R et al. Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation. Cell Death Dis. 9, 683 (2018)(PMID:29880899)
  41. Matsumoto G et al. N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Sci Rep. 8, 9585 (2018)(PMID:29941919)
  42. Lin X et al. Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy. Cell Death Dis. 9, 768 (2018)(PMID:29991758)
  43. Chen B et al. Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish. Front Endocrinol 9, 366 (2018)(PMID:30026731)
  44. Bak DH et al. Anti-apoptotic effects of human placental hydrolysate against hepatocyte toxicity in vivo and in vitro. Int J Mol Med. 42, 2569-2583 (2018)(PMID:30132515)
  45. Sil S et al. Cocaine Mediated Neuroinflammation: Role of Dysregulated Autophagy in Pericytes. Mol Neurobiol. (2018) In press.(PMID:30151726)
  46. Liu X et al. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucleic Acids Res. 46, 9601-9616 (2018)(PMID:30165671)
  47. Götzl JK et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 13, 48 (2018)(PMID:30180904)
  48. Jin GL et al. Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats. Front Pharmacol. 9, 989 (2018)(PMID:30214411)
  49. Osaki Y et al. Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II. Cell Death Dis. 9, 808(2018)(PMID:30042467)
  50. Sun Y et al. Ischemic Postconditioning Alleviates Cerebral Ischemia-Reperfusion Injury Through Activating Autophagy During Early Reperfusion in Rats. Neurochem Res. 43, 1826-1840 (2018)(PMID:30046966)
  51. Gkirtzimanaki K et al. IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion. Cell Rep. 25, 921-933.e5 (2018)(PMID:30355498)
  52. Chou LF et al. Effect of Trehalose Supplementation on Autophagy and Cystogenesis in a Mouse Model of Polycystic Kidney Disease. Nutrients. 11, pii: E42 (2018)(PMID:30585217)
  53. Benkafadar N et al. ROS-Induced Activation of DNA Damage Responses Drives Senescence-Like State in Postmitotic Cochlear Cells: Implication for Hearing Preservation. Mol Neurobiol. in press(PMID:30693443)
  54. Aki T et al. Formation of high molecular weight p62 by CORM-3. PLoS One. 14, e0210474 (2019)(PMID:30620762)
  55. Lu SZ et al. Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation. Transl Neurodegener. 8, 3 (2019)(PMID:30675347)
  56. Hoffmann AC et al. Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose. Sci Rep. 9, 544 (2019) (PMID:30679445)
  57. Ohashi T et al. Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice. PLoS One. 14, e0210068 (2019) (PMID:30689650)
  58. Scrivo A et al. Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production. Nat Commun. 10, 780 (2019)(PMID:30770803)
  59. Nakamura S et al. Suppression of autophagic activity by Rubicon is a signature of aging. Nat Commun. 10, 847 (2019)(PMID:30783089)
  60. Hsu YH et al. Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo. Free Radic Biol Med. 135, 235-244 (2019)(PMID:30878646)
  61. Nakajima S et al. Fat-specific protein 27α inhibits autophagy-dependent lipid droplet breakdown in white adipocytes. J Diabetes Investig. in press.(PMID:30927519)
  62. Slowicka K et al. Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis. Nat Commun. 10, 1834 (2019)(PMID:31015422)
  63. Wang Y et al. Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway. Front Physiol. 10, 494 (2019)(PMID:31105592)
  64. Zhu L et al. Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer. Cell Death Dis. 10, 383 (2019)(PMID:31097692)
  65. Homma T, Fujii J. An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice. Biochim Biophys Acta Gen Subj. 1863, 1108-1115 (2019)(PMID:30974160)
  66. Liu N et al. Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2 Α -mediated tumor progression. J Clin Invest. 129 631-646 (2019)(PMID:30431439)
  67. Wei R et al. Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen species production. Sci Rep. 9, 10366 (2019)(PMID:31316111)
  68. Yang Y et al. Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nat Commun. 10, 3759 (2019)(PMID:31434890)
  69. Kanazawa T et al. Effect of Ovariectomy and Ovarian Hormone Administration on Hepatic Autophagy in Female Rats. J Nutr Sci Vitaminol (Tokyo). 65, 357-361 (2019)(PMID:31474686)
  70. Tripathi A et al. Antiretroviral-Mediated Microglial Activation Involves Dysregulated Autophagy and Lysosomal Dysfunction. Cells. 8, pii: E1168 (2019)(PMID:31569373)
  71. Holdgaard SG et al. Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites. Nat Commun. 10, 4176 (2019)(PMID:31519908)
  72. Makanae Y et al. Dietary Aronia Melanocarpa Extract Enhances mTORC1 Signaling, but Has No Effect on Protein Synthesis and Protein Breakdown-Related Signaling, in Response to Resistance Exercise in Rat Skeletal Muscle. J Int Soc Sports Nutr. 16, 60 (2019)(PMID:31829236)
  73. Evi Goulielmaki et al. Tissue-infiltrating Macrophages Mediate an Exosome-Based Metabolic Reprogramming Upon DNA Damage. Nat Commun. 11, 42 (2020) (PMID:31896748)
  74. Kobayashi S et al. West Nile Virus Capsid Protein Inhibits Autophagy by AMP-activated Protein Kinase Degradation in Neurological Disease Development. PLoS Pathog. 16, e1008238 (2020)(PMID:31971978)
  75. Liu B et al. Scoparone Improves Hepatic Inflammation and Autophagy in Mice With Nonalcoholic Steatohepatitis by Regulating the ROS/P38/Nrf2 Axis and PI3K/AKT/mTOR Pathway in Macrophages. Biomed Pharmacother. 125, 109895 (2020)(PMID:32000066)
  76. Yoshikawa N et al. Plasma-activated Medium Promotes Autophagic Cell Death Along With Alteration of the mTOR Pathway. Sci Rep. 10, 1614 (2020)(PMID:32005941)
  77. Luciani A et al. Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency. Nat Commun. 11, 970 (2020)(PMID:32080200)
  78. Kobayashi M et al. Inhibition of autophagy in theca cells induces CYP17A1 and PAI-1 expression via ROS/p38 and JNK signalling during the development of polycystic ovary syndrome. Mol Cell Endocrinol. 508, 110792 (2020)(PMID:32199904)
  79. Ma YY et al. IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. Cell Death Dis. 11, 200 (2020)(PMID:32205851)
  80. Shizukuishi S et al. Streptococcus pneumoniae hijacks host autophagy by deploying CbpC as a decoy for Atg14 depletion. EMBO Rep. 21, e49232 (2020)(PMID:32239622)
  81. Wang SY et al. Cilostazol alleviate nicotine induced cardiomyocytes hypertrophy through modulation of autophagy by CTSB/ROS/p38MAPK/JNK feedback loop. Int J Biol Sci. 16, 2001-2013 (2020)(PMID:32398966)
  82. Wang M et al. Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. Part Fibre Toxicol. 17, 23 (2020)(PMID:32513195)
  83. Zhang X et al. Silencing of functional p53 attenuates NAFLD by promoting HMGB1-related autophagy induction. Hepatol Int. 14, 828-841 (2020)(PMID:32607732)
  84. Zhang X et al. Silencing of functional p53 attenuates NAFLD by promoting HMGB1-related autophagy induction. Hepatol Int. 14, 828-841 (2020)(PMID:32607732)
  85. Yang Y et al. sTim-3 alleviates liver injury via regulation of the immunity microenvironment and autophagy. Cell Death Discov. 6, 62 (2020)(PMID:32714569)
  86. Tokinoya K et al. Denervation-induced muscle atrophy suppression in renalase-deficient mice via increased protein synthesis. Physiol Rep. 8, e14475 (2020)(PMID:32741114)
  87. Yamamuro T et al. Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. Nat Commun. 11, 4150 (2020) (PMID:32811819)
  88. Nishikawa S et al. Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway. Antioxidants (Basel). 9, 842 (2020)(PMID:32916869)
  89. Fujiwara N et al. Autophagy regulates levels of tumor suppressor enzyme protein phosphatase 6.Cancer Sci. 111, 4371-4380 (2020)(PMID:32969571)
  90. Tripathi A et al. N-Acetylcysteine Reverses Antiretroviral-Mediated Microglial Activation by Attenuating Autophagy-Lysosomal Dysfunction. Front Neurol. 11, 840 (2020) (PMID:33013619)
  91. Sun S et al. Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI. Cell Death Dis. 11, 852 (2020)(PMID:33051438)
  92. Yamaguchi H et al. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nat Commun. 11, 5311 (2020) (PMID:33082312)
  93. Aragonès G et al. Autophagic receptor p62 protects against glycation-derived toxicity and enhances viability. Aging Cell. 19, e13257 (2020)(PMID:33146912)
  94. Shirai T et al. Effect of endurance exercise duration on muscle hypertrophy induced by functional overload. FEBS Open Bio. 11, 85-94 (2020) (PMID:33155405)
  95. Suginohara T et al. Effect of 2-deoxyglucose-mediated inhibition of glycolysis on the regulation of mTOR signaling and protein synthesis before and after high-intensity muscle contraction. Metabolism. 114, 154419 (2021)(PMID:33161019)
  96. Nozaki M et al. SQSTM1 L341V variant that is linked to sporadic ALS exhibits impaired association with MAP1LC3 in cultured cells. eNeurologicalSci. 22, 100301 (2020)(PMID:33319079)

Immunoprecipitation

  1. Watanabe Y et al. Autophagy controls centrosome number by degrading Cep63. Nat Commun. 7, 13508 (2016)(PMID:27869116)
  2. Zhao Q et al. Dual Roles of Two Isoforms of Autophagy-related Gene ATG10 in HCV-Subgenomic replicon Mediated Autophagy Flux and Innate Immunity. Sci Rep. 7, 11250 (2017)(PMID:28900156)
  3. Na Liu et al. ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1. Allergy Asthma Immunol Res. 13, e28 (2021)
  4. Serramito-Gómez I et al. Regulation of cytokine signaling through direct interaction between cytokine receptors and the ATG16L1 WD40 domain. Nat Commun. 11, 5919 (2020) (PMID:33219218)

Flow Cytometry

  1. Zhan R et al. Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation. Cell Death Dis. 9, 683 (2018)(PMID:29880899)

Immunocytochemistry

  1. Dupont N et al. Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe. 6, 137-49 (2009)(PMID:19683680)
  2. Itakura E, Mizushima N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol. 192, 17-27 (2011)(PMID:21220506)
  3. Higaki K et al. Chemical chaperone therapy: chaperone effect on mutant enzyme and cellular pathophysiology in β-galactosidase deficiency. Hum Mutat. 32, 843-52 (2011)(PMID:21520340)
  4. Myeku N, Figueiredo-Pereira ME. Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62. J Biol Chem. 286, 22426-40 (2011)(PMID:21536669)
  5. Huang C et al. Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One 6, e20975 (2011)(PMID:21687634)
  6. Seto S et al. Coronin-1a inhibits autophagosome formation around Mycobacterium tuberculosis-containing phagosomes and assists mycobacterial survival in macrophages. Cell Microbiol. 14, 710-27 (2012)(PMID:22256790)
  7. Sano O et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 590, 1576-85 (2016)(PMID:27135648)
  8. Takayama K et al. Dissection of ubiquitinated protein degradation by basal autophagy. FEBS Lett. 591, 1199-1211 (2017)(PMID:28369861)
  9. Yamaguchi T et al. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 11, eaan3638 (2018)(PMID:29438013)
  10. Gkirtzimanaki K et al. IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion. Cell Rep. 25, 921-933.e5 (2018)(PMID:30355498)
  11. Aki T et al. Formation of high molecular weight p62 by CORM-3. PLoS One. 14, e0210474 (2019)(PMID:30620762)
  12. Ding X et al. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy. 15, 1774-1786 (2019) (PMID:30957628)
  13. Puri R et al. Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts. Nat Commun. 10, 3645 (2019)(PMID:31409786)
  14. Omi J et al. The Inducible Amphisome Isolates Viral Hemagglutinin and Defends Against Influenza A Virus Infection. Nat Commun. 11, 162 (2020)(PMID:31919357)
  15. Kobayashi S et al. Characterization of a rat monoclonal antibody raised against ferroptotic cells. J Immunol Methods. 489, 112912 (2021)(PMID:33189725)

Immunohistochemistry

  1. Waguri S, Komatsu M. Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice. Methods Enzymol. 453, 181-96 (2009)(PMID:19216907)
  2. Urbanczyk A et al. PKCζ-interacting protein ZIP3 is generated by intronic polyadenylation, and is expressed in the brain and retina of the rat. Biochem J. 433, 43-50 (2011)(PMID:20979579)
  3. Chen H et al. Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy. J Cell Biol. 211, 795-805 (2015)(PMID:26598616)
  4. Cao QH et al. Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer. Am J Transl Res. 8, 3831-3847 (2016)(PMID:27725863)
  5. Liu WJ et al. Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy. Sci Rep. 7, 8643 (2017)(PMID:28819100)
  6. Tsuiji H et al. TDP-43 accelerates age-dependent degeneration of interneurons. Sci Rep. 7, 14972 (2017)(PMID:29097807)
  7. Sukseree S et al. Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7. Mol Neurobiol. (2018) In press.(PMID:29550918)
  8. Uemura N et al. Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve. Mol Neurodegener. 13, 21 (2018)(PMID:29751824)
  9. Miao X et al. Serum SQSTM1 is a potential predictor for chemotherapeutic efficacy against non-small cell lung . Int J Clin Exp Med. 11, 5811-5819 (2018)
  10. Adams O et al. A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. PLoS One 13, e0197610 (2018)(PMID:29897944)
  11. Qiu J et al. Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice. J Cancer Res Clin Oncol. 144, 1869-1886 (2018)(PMID:30043279)
  12. Chou LF et al. Effect of Trehalose Supplementation on Autophagy and Cystogenesis in a Mouse Model of Polycystic Kidney Disease. Nutrients. 11, pii: E42 (2018)(PMID:30585217)
  13. Lu SZ et al. Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation. Transl Neurodegener. 8, 3 (2019)(PMID:30675347)
  14. Ohashi T et al. Conophylline inhibits high fat diet-induced non-alcoholic fatty liver disease in mice. PLoS One. 14, e0210068 (2019)(PMID:30689650)
  15. Homma T, Fujii J. An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice. Biochim Biophys Acta Gen Subj. 1863, 1108-1115 (2019)(PMID:30974160)
  16. Morishita Het al. A critical role of VMP1 in lipoprotein secretion. Elife.. 8, e48834 (2019)(PMID:31526472)
  17. Kobayashi M et al. Inhibition of autophagy in theca cells induces CYP17A1 and PAI-1 expression via ROS/p38 and JNK signalling during the development of polycystic ovary syndrome. Mol Cell Endocrinol. 508, 110792 (2020)(PMID:32199904)

Immunofluorescence

  1. Evi Goulielmaki et al. Tissue-infiltrating Macrophages Mediate an Exosome-Based Metabolic Reprogramming Upon DNA Damage. Nat Commun. 11, 42 (2020)(PMID:31896748)
  2. Luciani A et al. Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency. Nat Commun. 11, 970 (2020)(PMID:32080200)
  3. Ma YY et al. IL28A protein homotetramer structure is required for autolysosomal degradation of HCV-NS5A in vitro. Cell Death Dis. 11, 200 (2020)(PMID:32205851)
  4. Noguchi M et al. β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice. Nutrients. 12, 2180 (2020)(PMID:32708051)
  5. Yamaguchi H et al. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nat Commun. 11, 5311 (2020) (PMID:33082312)

Other(Immuno-EM)

  1. Necchi V et al. Natural history of Helicobacter pylori VacA toxin in human gastric epithelium in vivo: vacuoles and beyond. Sci Rep. 7, 14526 (2017)(PMID:29109534)
  2. Sukseree S et al. Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7. Mol Neurobiol. (2018) In press.(PMID:29550918)

Other

  1. Jakobi AJ et al. Structural Basis of p62/SQSTM1 Helical Filaments and Their Role in Cellular Cargo Uptake. Nat Commun. 11, 440 (2020)(PMID:31974402)

※在庫につきましては2024年12月14日 00時05分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について：
*: 論文で報告されております（MBLでは未確認）。詳しくはデータシートをご覧ください。
**: 導入元からの情報です（MBLでは評価中もしくは未確認）。
※保存温度の表記について： RT: 室温
※本サイトの掲載製品は、品質改良のため予告なく仕様などの変更、または販売中止となる場合がございます。あらかじめご了承ください。

MBLCopyright (C)2015 Medical ＆ Biological Laboratories Co., Ltd. All Rights Reserve