抗体 製品詳細情報

Code No. D266-6
Anti-Mincle (Mouse) mAb-Biotin
価格(税別) ¥39,600
包装 100 µL
在庫 10以上
（2024/04/20 17:00時点）
クローナリティー Monoclonal
クローン 1B6
アイソタイプ
(免疫動物)		 Rat IgG1 κ
使用法 FCM　1:500  
免疫原(抗原) RBL-2H3 cells expressing full length mouse mincle
交差性 [Gene ID]

Mouse[56619]
性状 PBS/1% BSA/0.1% ProClin 150
保存温度 4°C
標識 Biotin
メーカー MBL
別称 Clec4e, C86253, Clecsf9, C-type lectin domain family 4, member e
背景 Macrophage-inducible C-type lectin (Mincle, also called as Clec4e and Clecsf9), a type II transmembrane C-type lectin receptor, is expressed mainly in macrophages. Mincle is selectively associated with the Fc receptor common g-chain which contains immunoreceptor tyrosine-based activation motif (ITAM) and activates macrophages to produce inflammatory cytokines and chemokines. Mincle expressing cells are activated by spliceosome associated protein 130 (SAP130) which is a component of small nuclear ribonucleoprotein released from dead cells.

Recently, Mincle is reported to recognize Mycobacterium tuberculosis as well as pathogenic fungus Malassezia species. Mincle is demonstrated to be an essential receptor for a mycobacterial glycolipid, trehalose-6,6’-dimycolate (TDM). The cytokine/chemokine production of macrophages which Malassezia or M.tuberculosis induces in Mincle-/- mice is significantly impaired. Mincle is considered to play a crucial role in immune responses to pathogens.
関連製品 D292-3 Anti-Mincle (Mouse) mAb
M191-3 Anti-FcεR1γ (FcRγ) (Mouse) mAb
D266-3M2 Anti-Mincle (Mouse) mAb (Functional Grade)
D292-3M2 Anti-Mincle (Mouse) mAb (Functional Grade)
D360-3 Anti-Mincle (Human) mAb (Functional Grade)
D266-3 Anti-Mincle (Mouse) mAb
製品カテゴリー 分野:免疫
データ

使用文献
  1.   
参考文献
  1. Miyake Y et al. C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity 38, 1050-62 (2013)
  2. Behler F et al. Role of Mincle in alveolar macrophage-dependent innate immunity against mycobacterial infections in mice. J Immunol. 189, 3121-9 (2012)
  3. Yamasaki S et al. C-type lectin Mincle is an activating receptor for pathogenic fungus Malassezia. PNAS 106, 1897-1902 (2009)
  4. Ishikawa E et al. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med. 206, 2879-2888 (2009
  5. Yamasaki S et al. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol. 9, 1179-88 (2008)

※在庫につきましては2024年04月20日 17時00分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について：
*: 論文で報告されております（MBLでは未確認）。詳しくはデータシートをご覧ください。
**: 導入元からの情報です（MBLでは評価中もしくは未確認）。
※保存温度の表記について： RT: 室温
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