抗体 製品詳細情報

Code No. D230-3
Anti-CD274 (PD-L1) (Human) mAb
価格(税別) ¥52,800
包装 100 µL (1 mg/mL)
在庫 10以上
（2024/04/24 17:00時点）
クローナリティー Monoclonal
クローン 27A2
アイソタイプ
(免疫動物)		 Mouse IgG2b
使用法 FCM　10 µg/mL (final concentration)  
IH　10 µg/mL (Heat treatment is necessary for paraffin embedded sections.)  
免疫原(抗原) Recombinant Human PD-L1 extracellular domain
交差性 [Gene ID]

Human[29126]
性状 1 mg/mL in PBS/50% glycerol, pH 7.2
保存温度 -20°C
標識 Unlabeled
メーカー MBL
別称 B7H1
背景 Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunogloblin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although <em>in vitro</em> study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-&gamma; GM-CSF and IL-10 from the T cells were enhanced. The role of PD-L1 is now debatable.
関連製品 D230-5 Anti-CD274 (PD-L1) (Human) mAb-PE
D092-3M2 Anti-CD274 (PD-L1) (Human) mAb (Functional Grade)
D133-3M2 Anti-CD279 (PD-1) (Human) mAb (Functional Grade)
D092-3 Anti-CD274 (PD-L1) (Human) mAb
D132-3 Anti-CD279 (PD-1) (Human) mAb
D132-4 Anti-CD279 (PD-1) (Human) mAb-FITC
D132-5 Anti-CD279 (PD-1) (Human) mAb-PE
D133-5 Anti-CD279 (PD-1) (Human) mAb-PE
製品カテゴリー 分野:免疫 がん アポトーシス 細胞膜表面抗原
データ

使用文献

Immunohistochemistry

  1. Hamanishi J et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. PNAS. 104, 3360-5 (2007)(PMID:1736065)
  2. Schuchmann M et al. The programmed death (PD)-1/PD-ligand 1 pathway regulates graft-versus-host-reactive CD8 T cells after liver transplantation. Am J Transplant. 8, 2434-44 (2008)(PMID:18925909)
  3. Hino R et al. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer 116, 1757-66 (2010)(PMID:20143437)
  4. Gadiot J et al. Overall survival and PD-L1 expression in metastasized malignant melanoma. Cancer 117, 2192-201 (2011)(PMID:21523733)
  5. Droeser RA et al. Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. Eur J Cancer 49, 2233-42 (2013)(PMID:23478000)
  6. Hamanishi J et al. Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer. J Clin Oncol. 33, 4015-22 (2015)(PMID:26351349)
  7. Wu X et al. PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients. Br J Cancer. 111, 1391-9 (2014)(PMID:25093496)
  8. Goto W et al. Eribulin Promotes Antitumor Immune Responses in Patients with Locally Advanced or Metastatic Breast Cancer. Anticancer Res. 38, 2929-2938 (2018)(PMID:29715119)
  9. Ito N et al. Clinical Significance of Programmed Death Ligand-1 Expression in Esophageal Squamous Cell Carcinoma. J Surg Res. 251, 321-328 (2020)(PMID:32200323)

※在庫につきましては2024年04月24日 17時00分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について：
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について：
*: 論文で報告されております（MBLでは未確認）。詳しくはデータシートをご覧ください。
**: 導入元からの情報です（MBLでは評価中もしくは未確認）。
※保存温度の表記について： RT: 室温
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