抗体 製品詳細情報

Code No. CM004-A64 プリントプリント
Anti-SynCAM (TSLC1/CADM1) mAb-Alexa Fluor® 647
価格(税別) ¥58,000
包装 100 µg/100 µL
在庫 10以上
(2022/08/10 17:30時点)
クローナリティー Monoclonal
クローン 3E1
アイソタイプ
(免疫動物)
Chicken IgY
使用法 FCM 1 µg/mL  
免疫原(抗原) Recombinant Fc-SynCAM fusion protein
交差性 [Gene ID]

Human[23705]

性状 1 mg/mL in PBS/1% BSA/0.1% ProClin 150
保存温度 4°C
標識 Alexa Fluor® 647
メーカー MBL
別称 cell adhesion molecule 1, BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, sTSLC-1, sgIGSF
背景 SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.
関連製品 CM004-3 Anti-SynCAM (TSLC1/CADM1) mAb
CM005-3 Anti-SynCAM (TSLC1/CADM1) (Human) mAb
PM084 Normal Chicken IgY
PM084-4 Normal Chicken IgY-FITC
PM084-5 Normal Chicken IgY-PE
CM004-4 Anti-SynCAM (TSLC1/CADM1) mAb-FITC
CM004-5 Anti-SynCAM (TSLC1/CADM1) mAb-PE
CM004-6 Anti-SynCAM (TSLC1/CADM1) mAb-Biotin
製品カテゴリー 分野:がん 神経科学
データ

参考文献
  1. Fogel AI et al. SynCAMs organize synapses through heterophilic adhesion. J Neurosci. 27, 12516-12530 (2007)(PMID: 18003830
  2. Fujita E et al. Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice. Am J Pathol. 171, 1800-1810 (2007)(PMID: 18055550
  3. Hollins F et al. Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: cooperative roles for CADM1, stem cell factor, and IL-6. J Immunol. 181, 2772-2780 (2008)(PMID: 18684968
  4. Hasstedt SJ et al. Cell adhesion molecule 1: a novel risk factor for venous thrombosis. Blood. 114, 3084-3091 (2009)(PMID: 19643986
  5. Hagiyama M et al. Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth. Am J Pathol. 174, 2278-2289 (2009)(PMID: 19435791
  6. Yang W et al. Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol. 176, 1238-1243 (2006)(PMID: 16394014
  7. Wakayama T et al. Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells. Biol Reprod. 76, 1081-1090 (2007)(PMID: 17314315

※在庫につきましては2022年08月10日 17時30分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation,
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization

ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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