トップ > 製品検索結果一覧 > Code No. PM037 Anti-GABARAP pAb

Code No. PM037

Anti-GABARAP pAb

価格(税別)

¥52,800

在庫

10以上

(2024/12/14 00:05時点)

包装

100 µL

This antibody reacts with GABARAP on Western blotting and Immunocytochemistry. It does not react with LC3 and GATE16.
データ
  • Western Blotting

  • Immunocytochemistry

クローナリティー Polyclonal クローン Polyclonal
アイソタイプ
(免疫動物)
Rabbit Ig (aff.)
使用法
WB
1:1,000  
IC
1:100  
免疫原(抗原) Carrier protein conjugated GABARAP N-terminal synthetic peptide
交差性
[Gene ID]

Human[11337], Mouse[56486], Rat[58974], Hamster[100767236]

性状 PBS/50% glycerol, pH 7.2
保存温度 -20°C 標識 Unlabeled メーカー MBL
別称 GABA(A) receptor-associated protein, MM46, ATG8A, GABARAP-a
背景 Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. LC3, GAPARAP (γ-aminobutyric-acid-type-A-receptor-associated protein), and GATE-16 (Golgi-associated ATPase enhancer of 16 kDa) have been identified as a homologue of yeast Atg8. These homologues have been characterized as modifiers in reactions mediated by hAtg7 (an E1-like enzyme) and hAtg3 (an E2-like enzyme) as in yeast Atg8 lipidation. These homologues also generate form II, which are recovered in membrane fractions. Generation of the form II correlates with autophagosome association. These results suggest that all mammalian Atg8 homologues receive a common modification to associate with autophagosomal membrane as the form II.
関連製品 M135-3 Anti-GABARAP mAb
PM038 Anti-GATE-16 pAb
PM072 Anti-VMP1 pAb
PM036 Anti-LC3 pAb
M152-3 Anti-LC3 mAb
M186-3 Anti-LC3 mAb
PD014 Anti-LC3 pAb
PM045 Anti-p62 (SQSTM1) pAb
M162-3 Anti-p62 (SQSTM1) (Human) mAb
PM066 Anti-p62 C-terminal pAb
M133-3 Anti-Atg3 mAb
PM039 Anti-Atg7 (Human) pAb
PM090 Anti-Atg8 (Filamentous fungi) pAb
M152-3MS Anti-LC3 mAb for My select sampler set
使用文献
使用文献募集中!本製品を使って論文を発表されましたら是非お知らせください。
  1. Maruyama Y et al. LC3B is indispensable for selective autophagy of p62 but not basal autophagy. Biochem Biophys Res Commun. 446, 309-15 (2014)(PMID:24582747)
  1. Tanida I et al. In vitro assays of lipidation of Mammalian Atg8 homologs. Curr. Protoc. Cell Biol. 646, 11.20.1-13 (2014)(PMID:25181299)
  1. Szalai P et al. Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs. Exp Cell Res. 333, 21-38 (2015)(PMID:25684710)

Western Blotting

  1. Mariño G et al. Autophagy is essential for mouse sense of balance. J Clin Invest. 120, 2331-44 (2010)(PMID:20577052)
  2. Polletta L et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy 11, 253-70 (2015)(PMID:25700560)
  3. Park S et al. O-GlcNAc modification is essential for the regulation of autophagy in Drosophila melanogaster. Cell Mol Life Sci. 72, 3173-83 (2015)(PMID:25840568)
  4. Winer H et al. Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins. Nat Commun. 9, 3744 (2018)(PMID:30218067)
  5. Saladini S et al. Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells. Cells 8, E49 (2019)(PMID:30646605)
  6. Qiao J et al. Identification of AaAtg8 as a marker of autophagy and a functional autophagy-related protein in Aedes albopictus. PeerJ. 6, e5988 (2018)(PMID:30498644)
  7. Saladini S et al. Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells. Cells. 8, pii: E49 (2019) (PMID:30646605)

Immunohistochemistry

  1. Li C et al. Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome. Nat Commun. 8, 1257 (2017)(PMID:29097652)
製品
カテゴリー
分野
オートファジー
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※在庫につきましては2024年12月14日 00時05分時点における在庫数を表示してあります。
※価格の赤色表示につきましては、キャンペーン価格の表示となっております。
※このサイトからは直接注文はできません。ご注意ください。
※使用法の表記について:
WB: Western Blotting, IH: Immunohistochemistry, IC: Immunocytochemistry, IP: Immunoprecipitation,
FCM: Flow Cytometry NT: Neutralization, IF: Immunofluorescence, RIP: RNP Immunoprecipitation,
ChIP: Chromatin Immunoprecipitation, CoIP: Co-Immunoprecipitation
DB: Dot Blotting, NB: Northern Blotting, RNA FISH: RNA Fluorescence in situ hybridization
※使用法・交差性の表記について:
*: 論文で報告されております(MBLでは未確認)。詳しくはデータシートをご覧ください。
**: 導入元からの情報です(MBLでは評価中もしくは未確認)。
※保存温度の表記について: RT: 室温
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